Ovaries path I Flashcards

1
Q

what are follicular cysts

A

common
form if no LH surge and cyst does’t rupture to release its egg, continues to grow and forms cyst
usually reabsorb after 2-3 menstrual cycles

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2
Q

what causes a corpus luteum cyst

A

if opening from released egg seals off the subsequent corpus luteum can grow into a cyst

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3
Q

what can occur with corpus luteum cyst

A

may hemorrhage or udnergo torsion

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4
Q

what is an endometrioma

A

chocoloate cysts from repeated menstural cycles

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5
Q

youn women with sudden unilateral low abdominal pain

A

torision of ovary

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6
Q

what do you have to rule out if suspect torsion of ovary

A

ectopic pregnancy

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7
Q

what is Tx for torsion of ovary

A

surgery to unwind ot remove

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8
Q

what is the #1 cause of torsion of ovary

A

teratoma

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9
Q

risk factors for ovarian torsion

A

increased length of ovarian ligament/large ovary

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10
Q

What are components of polycystic ovary disease

A

oligomenorrhea
hyperandrogenism: hisutisms, inc muscle mass, large clitoris, baldness, acne
polycystic ovaries
obesity, acanthosis nigricans, DM, insulin R, premature ASD, high cholesterol

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11
Q

what disease do you rule out for PCOD

A

thyroid problems, pituitary problems

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12
Q

what is stromal hyperthecosis

A

overlaps with PCOD
both ovaries enlarged with hormonally active ovarian stroma
most common in postmenopausal women
virilizaiton may be striking

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13
Q

how does ranking of hirsutism work

A

scale 0-4, 4 being the most hair

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14
Q

if suspect PCOD what are labs to order

A

Testosterone levels at 8 am
24 hr urine cortisol levels
DXM suppression test

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15
Q

definition of infertility

A

failure to conceive after 1 year of sex

> 6mo if >35 y.o

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16
Q

what is fecundity

A

likeliehood of pregnancy over time
25-50% <3 mo
85% in 1 yr

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17
Q

what can cause pale infertility

A

endocrine, poor sperm

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18
Q

23 y.o female complaining of infertility

labs to order

A

day 21 P
3 ng/mL= recent ovulation
endometrial Bx

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19
Q

if 23 y.o infertile patient is anovulatory what could be causes of infertility

A

PCOS: increased androgen, ovarian cysts

PRL levels, TSH, FSH

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20
Q

if 23 y.o infertile patient does have ovulation what could be cause of infertility and what lab do you do.

A

hysterosalpingogram to see if blocked or patent
blockage could be PID or mechanical
if patent could be endometriosis, uterine masses, lesion… etc

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21
Q

what lab level will determine if 40 y.o F has ovarian failure

A

if day 3 FHS levels are increased

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22
Q

majoirty of malignant ovarian tumors are what type

A

serous tumors, surface epithelial

cystadenomas, borderline tumors, adenocarcinomas type I and III

23
Q

what are the types of surface epithelial tumors of ovaries

A

serous
mucinous
endometroid

24
Q

what are the sex cord-stromal tumors of ovaries

A

granulosa, fibrothecomas and sertoli-leydig tumors

25
Q

what are the germ cell tumors of ovaries

A

teratoma, dysgerminoma, endodermal, sinus (yolk sac)

26
Q

second most common malignant ovarian tumors

A

endometroid tumors- adenocarcinoma type I and II

27
Q

when are ovarian cancers discovered

A

late presentaiton because often asymptomatic

28
Q

what are the hereditary assocaitions with ovarian cancer

A

BRCA 1 and 2

lynch II syndrome MSH2

29
Q

prognosis of ovarian cancer really depends on what

A

stage

30
Q

which ovarian cancers are mroe commonly b/l

A

serous and endometrial

31
Q

What is used to follow already Dx ovarian cancer

A

CA-125

32
Q

what decreases risk of ovarian cancer

A

tubal ligation, BCP

33
Q

wehre do most serous ovarian CA arise

A

distal fallopian tube

34
Q

what is a serous cystadenoma

A

benign common

lined by single layer epithlium

35
Q

what is a serous borderline carcinoma

A

more cytologic atypia but NO invasion
usually spread to peritoneum
good survival

36
Q

what is a serous adenocarcinoma

A

INVASIVE
type I is low grade- slow progression
type II is aggressive high grade and presents late (if mets <10 % survival

37
Q

histo of serous adenocarcinoma

A

single cells that line cyst wall and ciliated

fallopian tube also ciliated

38
Q

what classifies “borderline”

A

in between category

no evidence of invasion

39
Q

Tx for borderline carcinomas

A

remove

40
Q

what is exophytic serous carcinoma

A

surface ovary covered by neoplas

41
Q

what is cystic serous carcinoma

A

surface of ovary is smooth because neoplasm inside

42
Q

serous adenocarcinoma can have what unique histo cahracteristic that is pathoneumonic

A

psammomma bodies

43
Q

most mucinous tumors are benign or malignant

A

benign

44
Q

what utation is assoc with mucinous tumors or ovaries

A

KRAS

45
Q

what is pseudomyxoma peritonei

A

mucinous ascites with metastatic tumor on peritoneal surfaces

46
Q

what are endometroid tumors type II markers

A

p53, CDH1, MI

47
Q

what are the endometroid tumors type I markers

A

PTEN and KRAS and beta cetenin

48
Q

mutation assoc with clear cell carcinoma of ovaries

A

PTEN mutations or loss of heterozygosity PIK3CA mutation

49
Q

high grade serious carcinomas and high grade endometroid carcinomas are assoc with what mutations

A

p53

BRCA1

50
Q

cytological markers for high grade serous carcinoma of ovary

A

p53
WT1
Pax8
ER+

51
Q

cytologic markers for low grade serous carcinoma of ovary

A

WT1 Pax8

52
Q

cytologic markers for endometroid carcinomas of ovary

A

ER +
PAX8+
WT negative!

53
Q

cytologic markers for clear cell carcinoma of ovary

A

HNF beta+
negative WT!
ER negative!

54
Q

cytologic markers for mucinous carcinomas of ovary

A

CK20+
ER negative!
WT negative!