Vaccines Flashcards
attenuate vaccine?
Alive -use microbes that replicate but have reduced pathology
inactive vaccine?
Dead - uses microes, their products but are not able to reproduce
What do inactive vaccines often require to get immune response?
adjuvant
what is an adjuvant
substance that enhances the immune response to an antigen with which it is mixed
Advantages of attenuated vaccine?
small dose, few boosters, good membory, good Tc, Th and IgA immunity
Disadvantage of attenuated?
unstable(need a refridgerator), could revert to dangerous form, risky for immunocompromized
Disadvantage of inactivated vaccine?
large dose required, many boosters needed, poor memory, mainly IgG response
Advantages of inactivated vaccine?
stable, cant become pathogenic, not a risk to the immunodeficient.
What is the third type of vaccine?
DNA vaccine, they are plasmids that when injected should encourage host cells to produce correct antigen.
what is a vaccine?
preparation of antigenic material used to induce immunity to a pathogenic microbe
Herd immunity
immunity tht occurs when signifigant portion of a population has been vaccinated which provides a degree of protection to those who haven’t developed an immunity.
Why are the earliest vaccines at two months (except hep B)
Moms immunity is waining and if you do it to early, moms antibodies will block vaccine
Conjugate vaccine is what?
made up of bits and piece - new protein is added to antigent lacking protein (LPS) to make better vaccine
What is rotovirus?
Only dsRNA virus of signifigant value causing diarrhea and dehydration
What is haemophilus influenza?
G(-) bacterai respiratory droplets, capsule, respiratory drop, IgA protease
