UWorld-Rapid Review Flashcards

1
Q

ptosis, weakness of face muscles (i.e. mastication, EOMs), diplopia that worsens with use suggests what condition and what associated neoplasm

A

myasthenia gravis;

thymoma

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2
Q

shortened 4th and 5th digits; short stature; round face

A

pseudohypoparathyroidism (end-organ resistance to PTH, TSH, LH/FSH) aka Albright hereditary osteodystrophy

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3
Q

stained red by safranin-O

A

collagen, mast cell granules, or mucin

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4
Q

adult structure that runs through inguinal canal (in man, in woman) and its embryologic derivative

A

spermatic cord in men (note: processus vaginalis disappears); round ligament in women
both are derived from gubernaculum (note: ovarian ligament also derives from gubernaculum, but doesn’t run through inguinal canal)

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5
Q

expected pH, pCO2 and pO2 for pulmonary embolism

A

respiratory alkalosis (hyperventilation due to V/Q mismatch driven hypoxemia)=> high pH, low pCO2, low O2

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6
Q

brown colored patches/spots, flesh-colored papules, intertriginous freckling

A

Neurofibromatosis (von Recklinghausen’s) chromosome 17

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7
Q

antibiotic for which histamine release increases proportional to infusion rate

A

vancomycin (Red man syndrome)

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8
Q

heavy menses, pelvic pressure/pain, palpable pelvic mass in an African American woman

A

leiomyoma

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9
Q

pain passing stools, bloody in stool, Hx of vascular or heart disease (diminished pulses, past MI)

A

ischemic colitis:

on histology= mucosal hemorrhage and patchy necrosis

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10
Q

fasting hypoglycemia and hypoketonemia

A

Acyl-CoA dehydrogenase deficiency or another defect in beta-oxidation pathway

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11
Q

how many ATP produced per: NADH, FADH2, GTP

A

3 ATP per NADH, 2 ATP per FADH2, 1 ATP per GTP

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12
Q

how much net ATP produced in anaerobic (glycolysis) vs. aerobic metabolism

A

net 2 ATP produced in glycolysis;

net 38 ATP produced in anerobic metabolism

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13
Q

leukoplakia vs. lichen sclerosis

A

leukoplakia= white thickening of mucosal surfaces (i.e. oral) often due to EBV
lichen sclerosis= white thinning of squamous surfaces (i.e. labia majora or perineal skin) due to autoimmune disease (anti-ECM1)

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14
Q

is acute tubular necrosis typically in the cortex or the medulla of the kidney

A

medulla: less blood supply than cortex so more prone to ischemia

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15
Q

atrophy of villi in the small bowel on histology

A

Celiac’s (check for dermatitis herpetiformis)

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16
Q

notable toxicities of TCA’s

A

QRS prolongation and arrhythmia, anticholinergic effects, agitation, seizure, coma

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17
Q

sudden onset back pain, hematuria, oliguria and metabolic acidosis

A

ethylene glycol:

  • causes anion gap metabolic acidosis
  • causes calcium oxalate stones (along with Chron’s and vitamin C)
18
Q

sickle cell patient develops sepsis: what’s the microbe

A

most likely streptococcus (strep pneumo)

19
Q

recurrent lobar hemorrhages in an elderly patient

A

cerebral amyloid angiopathy (beta-amyloid deposition in cerebral arterial walls, not associated with systemic amyloidosis)

20
Q

a patient presenting with diabetes mellitus, necrolytic erythema and anemia likely has what condition

A

glucagonoma

21
Q

air in the biliary tree suggests what condition/complication

A

gallstone ileus; fistula formation between gallbladder and intestines allows stone to enter small intestines and get lodged in the ileocecal valve

22
Q

persistent disseminated mycobacterial and fungal infections suggest what immunologic defect

A

low IFN-gamma, needed to promote macrophage destruction of mycobacteria/fungi;
IL-12 receptor deficiency

23
Q

periodic, non-peristaltic contractions of the esophagus leading to crampy pain that resembles angina pectoris

A

diffuse esophageal spasm

24
Q

moldy grains can have what carcinogen and what associated cancer risk

A

aspergillus aflatoxins => HCC

25
a patient treated for leukemia or lymphoma develops symptoms of renal failure (high BUN or Cr): what's the problem and how could it have been prevented
tumor lysis syndrome; prevent with allopurinol/febuxostat or with rasburicase (turns uric acid into allantoin)
26
a patient with lung cancer starts developing ataxia: explain the etiology
paraneoplastic cerebellar degeneration: anti-Yo, anti-P/Q, and anti-Hu antibodies to the tumor cross-react with Purkinje cells in the cerebellum leading to degeneration
27
necrolytic erythema in the groin, abdominal pain, cheilosis, stomatitis can be the result of what condition
glucagonoma
28
how can you differentiate partial central DI from complete central DI?
osmolarity increase of >10% after ADH= partial | osmolarity increase of >50% after ADH=complete
29
what does danazol treat (2 things)
danazol=synthetic androgen that treats endometriosis and hereditary angioedema
30
patient complains of fatigue, mild weight gain and has elevated creatinine kinase; what's the next appropriate step in his care?
hypothyroid myopathy | -check serum TSH
31
antiphospholipase A2 antibodies are associated with what renal condition
membranous glomerulonephropathy
32
if you give your patient acyclovir, what side effect must you act to prevent
with acyclovir: hydrate your patient! acyclovir has a side effect of crystalline nephropathy and acute renal failure
33
mother has a rash that starts at the head and moves down as well as arthralgia and postauricular LAD; what will baby present with
this is rubella: fetal classic triad= PDA, cataracts, sensorineural deafness (may also see blueberry muffin rash similar to CMV)
34
which two infections in the mother can cause hydrops fetalis
parvovirus B19 and syphilis
35
your patient has achalasia and you suspect it has been caused by infection; what pathogen do you suspect and what would you treat with if the infection was ongoing
Trypanosoma cruzi; | treat with benznidazole or nifurtimox
36
what are p bodies and what do they do
p bodies are proteins found in the cytoplasm of eukaryotic cells that regulate translation by binding mRNA and storing them to release later
37
what is the function of HER-2
HER-2 is an epidermal growth factor receptor that has intrinsic tyrosine kinase and it promotes epidermal cell proliferation and differentiation
38
patients with adult-type coarctation are at increased risk of having what other condition
congenital berry aneurysms
39
what's the difference between scalded skin syndrome and toxic epidermal necrolysis
in scalded skin syndrome attachments between keratinocytes in the stratum granulosum are destroyed; in toxic epidermal necrolysis the epidermis-dermis junction is destroyed
40
what characteristic should a drug that is hepatically cleared have
high lipophilicity so it can be absorbed by the hepatocytes (in the kidney it would filter out and get reabsorbed right back so this would be unfavorable for kidney clearance)