UWorld-Rapid Review Flashcards
ptosis, weakness of face muscles (i.e. mastication, EOMs), diplopia that worsens with use suggests what condition and what associated neoplasm
myasthenia gravis;
thymoma
shortened 4th and 5th digits; short stature; round face
pseudohypoparathyroidism (end-organ resistance to PTH, TSH, LH/FSH) aka Albright hereditary osteodystrophy
stained red by safranin-O
collagen, mast cell granules, or mucin
adult structure that runs through inguinal canal (in man, in woman) and its embryologic derivative
spermatic cord in men (note: processus vaginalis disappears); round ligament in women
both are derived from gubernaculum (note: ovarian ligament also derives from gubernaculum, but doesn’t run through inguinal canal)
expected pH, pCO2 and pO2 for pulmonary embolism
respiratory alkalosis (hyperventilation due to V/Q mismatch driven hypoxemia)=> high pH, low pCO2, low O2
brown colored patches/spots, flesh-colored papules, intertriginous freckling
Neurofibromatosis (von Recklinghausen’s) chromosome 17
antibiotic for which histamine release increases proportional to infusion rate
vancomycin (Red man syndrome)
heavy menses, pelvic pressure/pain, palpable pelvic mass in an African American woman
leiomyoma
pain passing stools, bloody in stool, Hx of vascular or heart disease (diminished pulses, past MI)
ischemic colitis:
on histology= mucosal hemorrhage and patchy necrosis
fasting hypoglycemia and hypoketonemia
Acyl-CoA dehydrogenase deficiency or another defect in beta-oxidation pathway
how many ATP produced per: NADH, FADH2, GTP
3 ATP per NADH, 2 ATP per FADH2, 1 ATP per GTP
how much net ATP produced in anaerobic (glycolysis) vs. aerobic metabolism
net 2 ATP produced in glycolysis;
net 38 ATP produced in anerobic metabolism
leukoplakia vs. lichen sclerosis
leukoplakia= white thickening of mucosal surfaces (i.e. oral) often due to EBV
lichen sclerosis= white thinning of squamous surfaces (i.e. labia majora or perineal skin) due to autoimmune disease (anti-ECM1)
is acute tubular necrosis typically in the cortex or the medulla of the kidney
medulla: less blood supply than cortex so more prone to ischemia
atrophy of villi in the small bowel on histology
Celiac’s (check for dermatitis herpetiformis)
notable toxicities of TCA’s
QRS prolongation and arrhythmia, anticholinergic effects, agitation, seizure, coma
sudden onset back pain, hematuria, oliguria and metabolic acidosis
ethylene glycol:
- causes anion gap metabolic acidosis
- causes calcium oxalate stones (along with Chron’s and vitamin C)
sickle cell patient develops sepsis: what’s the microbe
most likely streptococcus (strep pneumo)
recurrent lobar hemorrhages in an elderly patient
cerebral amyloid angiopathy (beta-amyloid deposition in cerebral arterial walls, not associated with systemic amyloidosis)
a patient presenting with diabetes mellitus, necrolytic erythema and anemia likely has what condition
glucagonoma
air in the biliary tree suggests what condition/complication
gallstone ileus; fistula formation between gallbladder and intestines allows stone to enter small intestines and get lodged in the ileocecal valve
persistent disseminated mycobacterial and fungal infections suggest what immunologic defect
low IFN-gamma, needed to promote macrophage destruction of mycobacteria/fungi;
IL-12 receptor deficiency
periodic, non-peristaltic contractions of the esophagus leading to crampy pain that resembles angina pectoris
diffuse esophageal spasm
moldy grains can have what carcinogen and what associated cancer risk
aspergillus aflatoxins => HCC