UWorld 8/10 Flashcards
Acute lead exposure ssx?
- GI = abdominal pain, constipation
- Neurologic = headache, cognitive deficits, peripheral neuropathy
- Musculoskeletal = joint pains, muscle aches
- Hematologic = microcytic anemia w/ basophilic stippiling
- Anorexia
Which antipsychotic has the least risk of TD?
-clozapine
Chronic lead exposure ssx?
- *ssx of acute exposure (neurologic, GI, anemia, musculoskeletal, and anemia) plus:
1. Nonspecific ssx = fatigue, insomnia
2. HTN
3. Neuropsych ssx
4. Nephropathy (^^creatinine)
5. Reproductive effects = miscarriages, stillbirths
Most likely cause of microcytic anemia in kids?
-Pb poisoning
Tx of lead poisoning?
-chelation
What are 2 main things to look out for when tx with clozaril?
- Agranulocytosis
2. Seizures, it lowers the threshold
How is Parkinson’s dz dx?
- via PE
- 2/3 cardinal ssx must be present:
1. Resting tremor
2. Rigidity
3. Bradykinesia
How is appendicitis dx?
- via physical ssx + labs
- only if clinical picture is not typical is imaging required (either CT or ultrasound)
Imaging in dx of appedicitis?
- ONLY used when presentation is atypical and unclear
- normally this is a clinical dx!
Ssx of digoxin tox?
- Cardiac = life-threatening arrhythmias
- GI = anorexia, nausea, vomiting, abdominal pain
- Neurologic = fatigue, confusion, wkness, visual disturbances (yellow halos)
* *think vangough starry night
The addition of which medication can increase digoxin levels ?
-amioderone –> so decrease digoxin dose by 25-50% and then. He k the dig level weekly
Dx procedure of choice when suspecting renal colic in pregnancy?
-abdominal US
6 types of drugs that can cause acute pancreatitis?
- Diuretics = furosemide, thiazides
- Drugs for inflammatory bowel dz = sulfasalazine, 5-ASA
- Immunosuppressive agents = azathioprine
- HIV-related meds = didanosine, pentamidine
- Antibiotics = metronidazole, tetracycline
- Anti-seizure medications = valproic acid
Low grade fever during first 24 hrs post-partum?
-common and normal
Leukocytosis during the first 24 hrs postpartum?
-common and normal
Intrapartum chills?
-common and normal
Postpartum chills?
-common and normal
Lochia? Changes?
- discharge postpartum
- lochia rubia (red) for first few days –> lochia serosa (pale) after 3/4 days –> lochia alba (yellow/white)
- if foul smelling –> suspect endometritis!
Best way to dx primary syphillis?
- with dark field microscopy
- serum tests have high false neg results in primary stage!
Tx for epidural hematomas?
-emergency craniotomy!
What type II DM meds can cause wt gain?
- sulfonylureas!
2. Thiazolidinediones
What DM II meds can induce CHF in pts with heart dz?
-thiazolidinediones
What DM II medication can help with weight loss?
-GLP-1 receptor agonists!
Most common cause of acute liver failure in the US?
-acetaminophen toxicity
What are the three most common causes of severe acute hepatic injury? What is seen on labs?
- transaminase levels > 1000 U/L
1. Acute viral hepatitis
2. Ischemic hepatopathy (“shock liver”)
3. Toxic liver injury (esp with acetaminophen)
Tx of acetaminophen intox?
-acetylcysteine to tx liver injury
What are the 3 most common cardiac abnormalities seen in turner’s syndrome?
- Bicuspid aortic valve
- Coarctation of aorta
- Aortic root dilation –> increased risk of aortic dissection
Triad for normal pressure hydrocephalus?
- Gait disturbance
- Dementia
- Urinary incontinence
What is postcardiotomy syndrome?
- pericardial effusion that can occur days or months after cardiac surgery
- ssx:
1. Distant heart sounds
2. Hypotension
3. Distended jugular veins
Most common parasitic infection of the brain?
- neurocysticercosis caused by taenia solium (pork parasite)
- more common in a rural area with poorer sanitary conditions where pigs are raised
How is cystercosis contracted?
- by eating pork
- but also can get even if dont eat pork!
Most common manifestations of cystercosis?
- multiple, small fluid-filled cysts in brain parenchyma (and can be found elsewhere in body, spread hematogenously)
- most commonly causes neurologic sx (seizures, etc)
What commonly causes an abrupt onset of nausea and vomiting?
-ingestion of preformed toxin or chemical irritants
What are the 2 most common causes of preformed toxin acutely induced vomiting in the US?
- Staph aureus –> poultry and egg products (esp mayo), meat and meat products, milk and dairy products (cream filled paistries)
- Bacillus cerus (heat stable exotoxin) –> starchy foods (classically, reheated fried rice)
Penile fracture?
- surgical emergency!
- needs urgent urethral imaging (retrograde urethralgram) + surgical repair
Absent peristaltic waves in lower 2/3 of esophagus + decreased LES tone?
-Dismotility caused by scleroderma
What do you need to worry about after re-profusion?
-COMPARTMENT SYNDROME!
Embolic occlusion in a limb v compartment syndrome?
- BOTH cause: severe pain and paresthesias
- embolic occlusion causes: pulselessness, palor, an no local swelling
- compartment syndrome causes swelling and redness!!
Paralysis seen in botulism v tick borne dz?
- botulism = descending
- tick = ascending
Rapidly ascending paralysis with one limb that is worse?
-think tick-borne paralysis!