Urinary drugs Flashcards
What is the most common cause of transient urge incontinence
cystitis
What is the MOA of urge incontinence drugs
block acetylcholine action on the bladder and diminish detrusor muscle contraction
What drug class is oxybutynin (ditropan)
anticholinergic medication
what is the MOA of oxybutynin
Competitive antagonism of M3 subtype of the muscarinic acetylcholine receptor
What are the side effects of oxybutynin
dry mouth, dry eyes, less sweat, blurred vision, drowsiness, dizziness
what drug class is Tolterodine/ Detrol
anticholinergic
What drug class is imipramine (tofranil)
tricyclic antidepressant
What is the MOA of imipramine (tofranil)
Blocks reuptake of serotonin and norepinephrine and appears to diminish acetylcholine uptake in smooth muscle
What are side effects of imipramine (tofranil)
black box warning about increased risk for suicidal ideation and suicide.
What happens with imipramine over dose
death due to heart block can occur
What is the MOA of tolterodine (detrol)
Competitive antagonism of M2 and M3 subtypes of the muscarinic acetylcholine receptor
Which urinary drugs have a potential for interactions with drugs metabolized by cytochrome P450
tolterodine and oxybutynin
What drug class is Tamsulosin (flomax)
a1 receptor antagonist
What is the MOA of tamsulosin (flomax)
Smooth muscle relaxation via alpha adrenergic antagonism.
What drug class is finasteride (proscar)
5 alpha reductase inhibitor
What is the MOA of finasteride (proscar)
Blocks conversion of testosterone to dihydrotestosterone
What is low dose finasteride used to treat
male pattern baldness
What are side effects of finasteride
impotency
Which urinary drugs are category X
finasteride, ciprofloxin or other quinolones
What is Dr. Miller’s go-to drug for cystitis
Trimethoprim/ Sulfa DS
What antibiotic should not be used in pregnant or lactating women, or children
ciprofloxin and other quinolones
What happens when a person takes phenazopyridine (pyridium)
the urine changes to a bright orange color.
WHat effect does phenazopyridine (pyridium) have
It relieves the symptoms of urinary irritation, but does not treat the cause
What is a risk of using phenazopyridine
it may mask worsening symptoms, thus it is only prescribed for 2 days or so
