unknowns from Vivi's doc

Question 1

List the effects of Opium

Answer 1

• euphoria
• lethargy
• analgesia
• delirium

Question 2

what are public clinics in relation to US history?

Answer 2

They provided free morphine to addicts

Question 3

how did Vietnam increase the number of addicts?

Answer 3

it was easy to access and very pure

Question 4

what endogenous neurotransmitter attaches to the Mu receptor?

Answer 4

Beta Endorphin

Question 5

what Endogenous neurotransmitter attaches to the Delta receptor?

Answer 5

Enkephalin

Question 6

what Endogenous neurotransmitter attaches to the Kappa receptor?

Answer 6

Dynophins

Question 7

what three subtypes of receptors are involved in antinociceptive and analgesic mechanisms at both spinal and supraspinal levels?

Answer 7

Mu, Delta, and Kappa

Question 8

what is the action of the Mu receptors

Answer 8

It’s a respiratory depressant + GI

Question 9

what is the action of the delta receptors?

Answer 9

development of tolerance

Question 10

what is the action of the kappa receptors?

Answer 10

involved in sedation +GI

Question 11

Morphine is an agonist for all three receptors but is strongest for which of the three?

Answer 11

Mu

Question 12

All opiates are agonists for what systems

Answer 12

endorphin systems

Question 13

what experiment with mice provided proof of Mu receptors and dependence?

Answer 13

When they knocked out mice with no Mu receptors they were more sensitive to pain and did not become dependent on morphine.

Question 14

What are the three types of hallucinogens

Answer 14

1) Indole Hallucinogens
2) Catechol hallucinogens
3) Anticholinergic hallucinogens

Question 15

Indole hallucinogens

Answer 15

serotonin agonist

Question 16

Catechol hallucinogens

Answer 16

norepinephrine and dopamine agonists

Question 17

Anticholinergic hallucinogens

Answer 17

acetylcholine antagonists

Question 18

LSD was investigated as …

Answer 18

• psychotherapy
• a truth serum
• mind control

Question 19

what is catechol hallucinogens pharmacologyy?

Answer 19

Vesicle tries to store amphetamine so Norepinephrine and dopamine leak into the synapse and spontaneous release.

Question 20

what was MKUUltra

Answer 20

a CIA program to investigate LSD, all records destroyed.

Question 21

what is peyote’s mechanism of action

Answer 21

It is a dopamine agonist and there is some stimulation in norepinephrine as well, and it has glutamate action

Question 22

what are the three drugs that anticholinergic hallucinations have?

Answer 22

Atropine, Scopolamine, and Hyoscyamine

Question 23

what drug does deadly nightshade contain

Answer 23

atropine

Question 24

what drug does the mandrake root contain

Answer 24

all of the anticholinergic hallucinations drugs:
- Atropine
-Scopolamine
- Hyoscyamine

Question 25

what doe Henbane contain?

Answer 25

scopolamine

Question 26

what drug does Datura contain

Answer 26

all of the anticholinergic hallucinations drugs: - Atropine -Scopolamine - Hyoscyamine

Question 27

A motivational Syndrom

Answer 27

chronic, long term, loss of interest in goals

Question 28

The LaGuardia Report

Answer 28

describes A motivational syndrome and the commission recommended decriminalization of marijuana.

Question 29

what are testosterone's two effects with steroids?

Answer 29

Androgenic: secondary sexual characteristics Anabolic: contrastive metabolism and building tissues (increase protein synthesis)

Question 30

Steroids method of action

Answer 30

Cytoplasmic receptors-----> translocation to nucleus------> protein synthesis

Question 31

what do we know about Exelon and cognitive enahancers

Answer 31

when there was research done on Exelon, students got better SAT scores and chess players did better in tournament.

Question 32

what is Disulfiram (antabuse)

Answer 32

It is used in longer term support for drug addiction and in alcohol metabolized to acetaldehyde, the drug blocks aldehyde dehydrogenase.

Question 33

what are the three main points of this course

Answer 33

1) drug taking is a behavior 2) drug use is a part of our society 3) the drug problem isn't a war

Question 34

three ways of defining dangerous

Answer 34

1) toxicity level 2) how you use and where you use it 3) the concept of dangerousness has to be constantly revaluated.