Univ IV Review Flashcards

1
Q

List the five basic functions of the respiratory system

A
  1. Surface area for gas exchange
  2. Move air to and from the gas exchange area
  3. Protect respiratory system
  4. Producing sounds
  5. Detect odors
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2
Q

What structures make up the upper respiratory system

A

Nose, nasal cavity, paranasal sinuses, and pharynx

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3
Q

What structures make up the lower respiratory system

A

Larynx, trachea, bronchi, bronchioles, and alveoli

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4
Q

What are alveoli

A

Air-filled pockets where gas exchange takes place

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5
Q

What is the function of the paranasal sinuses

A

Produce mucus to protect nasal cavity

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6
Q

What is the main function of the nasal mucosa

A

Prepare air for arrival at the lower respiratory system

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7
Q

What is the main function of the larynx

A

Protect the glottis

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8
Q

What is the glottis

A

The vocal folds and the space between them

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9
Q

What is the role of the epiglottis

A

Prevents liquids and solids from entering the respiratory tract

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10
Q

What are type I pneumocytes

A

Squamous epithelial cells. The site of gas exchange.

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11
Q

What are type II pneumocytes

A

Produce surfactant

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12
Q

What is the function of alveolar macrophages

A

Phagocytize any invading particles

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13
Q

What is external respiration

A

All the processes involved in gas exchange between the body and the external environment

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14
Q

What is internal respiration

A

Absorption of O2 and release of CO2 by bodily cells

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15
Q

What is cellular respiration

A

The biochemical pathways responsible for O2 absorption and generation of CO2 by mitochondria

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16
Q

What is pulmonary ventilation

A

Breathing - moving air in and out of the lungs

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17
Q

What are hypoxia and anoxia

A

Hypoxia - low tissue O2 levels

Anoxia - O2 supply cut off completely

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18
Q

What is atmospheric pressure at sea level

A

760 mm Hg

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19
Q

What does Boyle’s Law state

A

The pressure of a gas is inversely proportionate to its volume

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20
Q

What is compliance of the lungs

A

How easily the lungs expand. Higher compliance = inflate easier

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21
Q

What factors affect the compliance of the lungs

A

Connective tissue, surfactant production, mobility of thoracic cage

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22
Q

What is the intrapulmonary pressure during inhalation in quiet breathing

A

759 mm Hg

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23
Q

What is a respiratory cycle

A

A single inhalation and exhalation

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24
Q

What is tidal volume

A

The amount of air you move in and out of your lungs during a normal respiratory cycle (quiet breathing)

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25
Q

What is pneumothorax

A

Air entering the pleural cavity

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26
Q

What is atelectasis

A

Recoiling of the elastic fibers of the lungs, aka “collapsed lung”

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27
Q

Which two muscles are primarily used during quiet breathing

A

Diaphragm and external intercostals

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28
Q

List all of the accessory muscles that are used in inhalation

A
  • Sternocleidomastoid
  • Scalenes
  • Pectoralis minor
  • Serratus anterior
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29
Q

List all of the accessory muscles that are used in exhalation

A
  • Rectus abdominis
  • Internal intercostals
  • Abdominal obliques
  • Transversus abdominis
  • Transversus thoracis
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30
Q

What is a normal respiratory rate

A

12 to 18 breaths per minute

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31
Q

What is respiratory minute volume and how is it calculated

A

Amount of air moved each minute = [Respiratory Rate] x [Tidal Volume]

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32
Q

What is alveolar ventilation and how is it calculated

A

Amount of air reaching the alveoli per minute = [Respiratory Rate] x [Tidal Volume - Anatomic Dead Space]

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33
Q

What is the composition of ambient air at sea level

A
  • 78.6% N2
  • 20.9% O2
  • 0.5% H2O
  • 0.04% CO2
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34
Q

What is the partial pressure of a gas

A

The pressure contributed by a single gas in a mixture of gasses

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35
Q

How do you calculate the partial pressure of O2 at sea level

A

760 x 0.209 (= 158.84 mm Hg)

36
Q

What does Henry’s Law state

A

At a given temperature, the amount of a particular gas in solution is directly proportional to the partial pressure of that gas

Note: This is what causes O2 to enter the blood at the lungs, and so on

37
Q

Does alveolar air contain more or less CO2 than atmospheric air, and why?

A

Incoming air mixes with air remaining in the alveoli from the previous respiratory cycle. For this reason, alveolar air contains more CO2 (and less O2) than atmospheric air.

38
Q

Why is the PO2 of exhaled air higher than the PO2 of alveolar air

A

Alveolar air mixed with air in the anatomical dead space as it is exhaled

39
Q

Explain how the autonomic nervous system works with the respiratory system to dilate and constrict blood vessels and bronchioles

A

PO2 increase and CO2 decrease in the alveoli = vasodilation and bronchoconstriction

PO2 decrease and CO2 increase in the alveoli = vasoconstriction and bronchodilation

40
Q

What are the two ways by which oxygen is transported in the blood

A
  1. 5% bound to hemoglobin (Hb)

1. 5% dissolved in plasma

41
Q

What is hemoglobin saturation

A

The percentage of heme units containing bound oxygen at any given moment

42
Q

How does the PO2 of plasma affect hemoglobin saturation

A

Hemoglobin carries and releases O2 in response to changes in the partial pressure of oxygen. As PO2 increases, Hb binds to O2. As pressure decreases, it releases oxygen.

43
Q

Why does hyperventilating increase the saturation of hemoglobin from 97.5% to 100%

A

Hyperventilation –> Alkalosis –> Curve shifts left and up

44
Q

What is the relationship between hemoglobin saturation and pH

A

Higher pH shifts curve to the left, increases saturation

45
Q

How is hemoglobin saturation affected by temperature

A

Colder temperatures shift the curve to the left, increase saturation.

46
Q

How does BPG affect oxygen release from hemoglobin molecules

A

More BPG shifts the saturation curve to the RIGHT, decreases saturation.

47
Q

How is fetal hemoglobin different from adult hemoglobin

A

Fetal Hb binds to oxygen more readily, shifts curve to the left.

48
Q

How is CO2 transported in the blood

A
  • 70% transported as HCO3-
  • 23% bound to Hb (carbaminohemoglobin)
  • 7% dissolved in plasma
49
Q

What is the chloride shift

A

HCO3- moving out of RBCs and Cl- moving into RBCs via countertransport. Requires no ATP.

50
Q

What is hemoglobin attached to CO2 called

A

Carbaminohemoglobin

51
Q

What happens to the interstitial PO2 and PCO2 when peripheral tissues become more active

A

Interstitial PO2 falls and PCO2 rises

52
Q

How is oxygen and carbon dioxide transport and removal affected at active peripheral tissues

A

More oxygen is delivered and more carbon dioxide is carried away

53
Q

What are the two components of the respiratory rhythmicity centers of the medulla oblongata

A

Dorsal Respiratory Group (DRG) and Ventral Respiratory Group (VRG)

54
Q

(Chapter 24)

What structures make up the digestive system

A

Oral cavity, pharynx, esophagus, stomach, small intestine, large intestine

55
Q

List the six integrated steps of the digestive system

A
  1. Ingestion
  2. Mechanical processing
  3. Digestion
  4. Secretion
  5. Absorption
  6. Excretion
56
Q

What are mesenteries

A

Connects the parietal peritoneum to the visceral peritoneum

57
Q

What is segmentation

A

The small intestine and some portions of the large intestine undergo cycles of contraction that churn and fragment the bolus, mixing the contents with intestinal secretions

58
Q

List the three pairs of salivary glands and describe their secretions

A

Parotid: Large amounts of salivary amylase (breaks down carbohydrates)

Sublingual: Buffer and lubricate

Submandibular: Mixture of buffers, glycoproteins called mucins, and salivary amylase

59
Q

What are the important functions of saliva

A
  • Lubricate the mouth
  • Lubricate food in the mouth
  • Dissolve
  • Contains salivary amylase and lingual lipase to begin digestion
60
Q

What is the role of the mucus that covers the interior surface of the stomach

A

An alkaline mucous layer that protects epithelial cells against the acid and enzymes in the gastric lumen

61
Q

What important products are secreted by the parietal cells of the gastric glands

A

HCl and Intrinsic factor (helps with absorption of B12)

62
Q

How is HCl produced in the stomach

A
  • Carbonic acid (H2CO3) is produced and dissociates into HCO3 and H+
  • H+ is is transported into the lumen
  • HCO3 is exchanged with Cl- ions from interstitial fluid
63
Q

What is the alkaline tide

A

Parietal cells are excreting enough HCO3 (while making HCl) to raise the body’s pH significantly

64
Q

What is the role of stomach acid (HCl)

A
  • Kills most microorganisms ingested with food
  • Denatures proteins and deactivates most enzymes in food
  • Breaks down plant cell walls and connective tissues in meat
  • Essential for activation and function of pepsin
65
Q

What important compound is secreted by the chief cells of the gastric glands

A

Pepsinogen (which is then activated by HCl)

66
Q

What are the functions of gastrin that is released by the pyloric glands

A

Gastrin stimulates secretion by both parietal and chief cells, as well as contractions of the gastric wall that mix and stir the gastric contents

67
Q

What are gherkin, lepton, and obestatin

A

Gherkin - induces hunger
Lepton - induces satiety
Obestatin - thought to decrease hunger and thirst

68
Q

Describe the three phases of gastric regulation

A

Cephalic phase: begins when you see, smell, taste, or think of food
Gastric phase: begins with the arrival of food in the stomach
Intestinal phase: begins when chyme first enters the small intestine

69
Q

What stops the digestion of lipids and carbohydrates in the stomach

A
  • Epithelial cells are covered by an alkaline mucous
  • Lack of transport mechanisms
  • Impermeable to water
  • Digestion is not yet complete
70
Q

What is the role of pepsin in the stomach

A

Digests protein

71
Q

What is the function of the duodenal glands

A

Helps raise pH of chyme from 1-2 to 7-8

72
Q

What are the three duodenal hormones

A
  • CCK (cholecystokinin)
  • Secretin
  • GIP (gastric inhibitory polypeptide)
73
Q

What is CCK

A

Cholecystokinin. Released when partially digested proteins and fat arrive at the duodenum.

  • Stimulates gallbladder to release bile
  • Inhibits gastric emptying
74
Q

What is secretin

A

Released when acidic chyme arrives at the duodenum. Stimulates the release of HCO3- from the pancreas.

75
Q

What is GIP

A

Gastric inhibitory polypeptide. Released when simple sugars arrive at the duodenum. Stimulates pancreas to release insulin.

76
Q

How does the liver stabilize blood glucose levels

A

If glucose levels rise - synthesize glycogen and lipids

If glucose levels fall - breakdown glycogen and synthesize glucose

77
Q

What percentage of cardiac output is received by the liver

A

25 percent

78
Q

How are antibodies handled by the liver

A

The liver absorbs and breaks down antibodies, releasing amino acids for recycling

79
Q

How are toxins addressed at the liver

A

Lipid-soluble toxins are stored in lipids, where they cannot damage cells

Other toxins are removed and broken down or excreted in bile

80
Q

What are the components of bile

A

Bile consists mostly of water, with minor amounts of ions, bilirubin (a pigment derived from hemoglobin), cholesterol, and an assortment of lipids collectively known as bile salts

81
Q

What is emulsification

A

Bile salts break fat into micelles

82
Q

What is the primary function of the cecum

A

Begins the process of compaction

83
Q

List the three vitamins that are produced by bacteria in the colon, and what are their functions

A

K - fat-soluble and required for synthesis of the four clotting factors

Biotin - water-soluble and important in various reactions, notably those of glucose metabolism

B5 - water-soluble and required in the manufacture of steroid hormones and some neurotransmitters

84
Q

What are the three classes of digestive enzymes

A

Lipase, amylase, protease

85
Q

What are the fat-solvable vitamins

A

A, D, E, K

86
Q

What are the water-soluble vitamins

A

B and C vitamins

87
Q

How is vitamin B12 absorbed

A

Bound to intrinsic factor