Unit V Review Flashcards
Chapter 25 What is metabolism
All the chemical reactions that take place in an organism
What is cellular metabolism
Chemical reactions within cells, which create energy
What is catabolism
The breakdown of organic molecules
What is anabolism
Synthesis of new organic molecules
What are the four reasons why cells synthesize new organic components
- Maintenance and repair 2. Support growth 3. Produce secretions 4. Store nutrient reserves
Which fuel source is used first by a cell that has an excess of fats, carbohydrates, and proteins? Why?
Carbohydrates. Glucose is the most efficient energy source, as fats and proteins must first be converted to other things before they can be used. (Fats are second choice, and protein is third)
Which step in the catabolism of glucose takes place in the cytosol of the cell
Glycolysis
What is the difference between aerobic and anaerobic metabolism
Aerobic = uses O2, anaerobic = does NOT use O2 Note: Glycolysis is ANAEROBIC, while reactions inside the mitochondria are aerobic
What is glycolysis
Catabolism of one glucose (6 carbon) to two pyruvate (3 carbon). (Glucose –> Pyruvic Acid –> Pyruvate)
Where does glycolysis take place in the cell
In the cytosol
Why is glycolysis considered to be an anaerobic process
It doesn’t use oxygen
How many carbon, hydrogen, and oxygen atoms are found in one molecule of glucose
C6 H12 O6
How many molecules of pyruvic acid are produced from the catabolism of one glucose molecule
Two
What is pyruvate
At the normal pH inside cells, each pyruvic acid (C3H4O3) molecule loses a hydrogen ion and exists as a negatively charged ion (called pyruvate - C3H3O3)
Which atoms in a glucose molecule are “harvested” and used to drive the process that synthesizes ATP from ADP
Hydrogen (pyruvate = C3H3O3)
In order for pyruvate to enter the citric acid cycle, what gas has to be available
O2
The citric acid cycle takes place in which organelle
Mitochondria
How is acetyl-CoA produced
NAD and coenzyme A react with pyruvate (C3H3O3) to yield: 1x acetyl-CoA (CH3CO) 1x carbon dioxide (CO2) 1x NADH
What is the main function of the citric acid cycle
To remove hydrogen atoms from organic molecules and transfer them to coenzymes
What acid binds to the acetyl group carried by CoA to form citric acid
Oxaloacetic acid (4 carbons: C4H4O5)
What enzymes are responsible for “harvesting” the hydrogen atoms in the citric acid cycle
NAD or FAD
What is oxidative phosphorylation and where does it take place
Produced more than 90% of ATP used by bodily cells. Takes place in the ETS (electron transport system - a series of integral and peripheral proteins in the inner mitochondrial membrane)
What compound is a byproduct of ATP synthesis
The basis of oxidative phosphorylation is the formation of water, a very simple reaction: 2(H2) + O2 = 2(H2O)
Why is oxidative phosphorylation considered an aerobic process
It uses oxygen [2(H2) + O2 = 2(H2O)]
What is the net gain in ATP molecules from the complete catabolism of one glucose molecule
36 molecules of ATP: 2 from glycolysis 4 from the NADH generated in glycolysis 2 from the citric acid cycle (by means of GTP) and 28 from the ETS
What is gluconeogenesis
The synthesis of glucose from noncarbohydrate precursors, such as lactate, glycerol, or amino acids
What precursor molecules are used in gluconeogenesis
Lactate, glycerol, or amino acids Note: Fatty acids cannot be used for gluconeogenesis, because their catabolic pathways produce acetyl-CoA!
What is glycogen and in which two organs is it mainly stored
Main form of glucose storage in the body. Stored primarily in the liver (400 calories) and muscles (800-1200 calories)
What is glycogenesis
Conversion of glucose to glycogen
What is glycogenolysis
Breakdown of glycogen
What atoms make up lipid molecules
Carbon, hydrogen and oxygen
What are the products of triglyceride catabolism
Glycerol and free fatty acids (FFA)
What is glycerol converted to in the cytosol
Pyruvate
What is beta oxidation
A sequence of reactions which converts FFA to 2-carbon acetic acid fragments, which are then converted to acetyl-CoA and enter the citric acid cycle
How many ATP molecules are synthesized when an 18 carbon fatty acid molecule is catabolized
144 ATP
Why do cells prefer to use carbohydrates for the synthesis of ATP during periods of high energy demand
Lipids cannot provide ATP as quickly as carbohydrates (glucose)
Why can almost any organic substrate be used in lipogenesis
The synthesis of most types of lipids begins with acetyl-CoA, and lipids, amino acids, and carbohydrates can be converted to acetyl-CoA
What is the most common form in which lipids circulate through the bloodstream
Most lipids circulate through the bloodstream as lipoproteins
Which cells are major users of free fatty acids
Liver cells, cardiac muscle cells, skeletal muscle fibers, and many other body cells can metabolize free fatty acids
What are lipoproteins
Lipid–protein complexes that contain large insoluble glycerides and cholesterol
What is the major constituent of chylomicrons and what is its main function
About 95 percent of the weight of a chylomicron consists of triglycerides
What are the major constituents of Low-Density Lipoproteins (LDL) and what is its function
Cholesterol, phospholipids, and few triglycerides They deliver cholesterol to peripheral tissues
Why is LDL referred to as “bad cholesterol”
Because the cholesterol may wind up in arterial plaques
What are the major constituents of High-Density Lipoproteins (HDL) and what is its function
Equal amounts lipid (cholesterol and phospholipids) and protein Transports excess cholesterol from peripheral tissues back to the liver for storage or excretion in the bile
How many amino acids are responsible for the synthesis of the hundreds of thousands of different proteins in the human body
20 amino acids
What is transamination
Attaches the amino group of an amino acid to a keto acid. This transfer converts the keto acid into an amino acid that can enter the cytosol, where it can be used for protein synthesis. In the process, the original amino acid becomes a keto acid that can be broken down in the citric acid cycle.
What is deamination
Prepares an amino acid for breakdown in the citric acid cycle
Why is the urea cycle important for the maintenance of homeostasis
Deamination produces toxic ammonium ions, which are neutralized into urea in the urea cycle
Why is protein catabolism an impractical source for quick energy
- More difficult to break apart than carbohydrates 2. Produces toxic ammonium ions 3. Proteins are vital components of cells
What are essential amino acids
10 amino acids which must come from diet and cannot be synthesized by the body
What are nonessential amino acids
Can be synthesized by the body on-demand
What is the role of the liver in metabolic regulation
The liver is the focal point of metabolic regulation: 1. Converts many enzymes to breakdown or synthesize needed carbs/lipids/amino acids 2. Large blood supply to monitor and adjust nutrient composition 3. Large energy reserves in glycogen
How are lipids stored in adipose tissue
Triglycerides
What is the role of skeletal muscles in energy storage and utilization
- Muscle contains substantial glycogen reserves 2. Contractile proteins can be broken down for amino acids to use as energy
What is unique about the energy needs of neural tissue
- Neural tissue has no reserves of carbs, lipids or amino acids. 2. Neurons need glucose (only), and cannot break down other molecules for energy Without glucose, the CNS will fail, and the person will fall unconscious
What is the absorptive state
Following a meal, cells absorb nutrients to be used for growth, maintenance, and energy reserves
What is the post-absorptive state
Metabolic reactions are focused on maintaining blood glucose levels that meet the needs of neural tissue
How are ketone bodies formed
Byproduct of fatty acid metabolism produced in the liver
How do peripheral tissues utilize ketones
Cells in peripheral tissues absorb ketone bodies and reconvert them to acetyl-CoA for breakdown in the citric acid cycle
What causes ketoacidosis
During prolonged starvation, ketone levels rise, and eventually buffering capacities are exceeded and a dangerous drop in pH takes place
How does the liver stabilize blood glucose levels in the post-absorptive state
First by the breakdown of glycogen reserves and later by gluconeogenesis
What are complete proteins
Proteins which provide all the essential amino acids (Some foods in the dairy and protein groups—specifically, beef, fish, poultry, eggs, and milk—provide all the essential amino acids in sufficient quantities. They are said to contain complete proteins.)