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TRI 3 - PH > Unit 6 - Exam 2 > Flashcards

Unit 6 - Exam 2 Flashcards

1
Q

Describe the Blood brain barrier

A

Selective filter that protects brain and spinal cord

Barrier formed by tight junctions that occur between capillary endothelial cells

Things that cross have carrier mediated transport systems

Drugs are developed to take advantage of the transport system and move things across

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2
Q

Describe the action of ACH

A

Cognition and memory

Excitatory

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3
Q

Describe the action of Dopamine

A

Regulates motor control at the basil ganglia

Inhibitory

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4
Q

Describe the action of norepinephrine

A

Pons/ reticular formation

Inhibitory

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5
Q

Describe the action of serotonin

A

Pons/ brainstem to spinal cord and hypothalamus
Mediates panful stimuli
Role in mood and behavior
Inhibitory

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6
Q

Describe the action of amino acids

A

GABA - Inhibitory

Glutamate, aspirate - Excitatory

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7
Q

Describe the action of Peptides

A

Substance P

Mediate painful stimuli

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8
Q

Generally describe Sedative-Hypnotic drugs name some of the drug classes

A

Promote sleep
Calming effect
Benzodiazepine’s
Nonbenzodiazepines

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9
Q

Describe Benzodiazepines

A

Used for sleep and as an antianxiety
Safer than barbiturates
Increases inhibitory effects of GABA hyperpolarizing cells with chloride

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10
Q

Describe Nonbenzodiazepines

A 
Barbiturates
Addictive
Inhibitory effects of GABA
Releases glycine - also inhibitory
Decreases excitation caused by glutamate
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11
Q

Name some Barbiturates

A

Ambien
Sonata
Lunesta

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12
Q

What are some AE of Sedative-Hypnotics

A 
Residual effects/ hangover
Tolerance/ dependence
Ante retrograde amnesia
Complex behaviors - sleep walking
GI discomfort, dry mouthy, sore throat
Cardiovascular and respiratory depression
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13
Q

Name some anti anxiety medications

A

Benzodiazepines
Buspirone
Antidepressants
Beta blockers

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14
Q

What are some AE of antidepressants

A

Sedation
Psychomotor impairment
Addiction
Rebound anxiety

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15
Q

What is the pathophysiology of depression

A

increased receptor sensitivity
-or-
lack of neurogenesis in hippocampus

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16
Q

Describe some antidepressant classes and how they work

A

SSRI - block serotonin reuptake
SNRI - block Norepinephrine reuptake
MAOI - allow neurotransmitters to stay longer at synaptic cleft by inhibiting enzymes
TCA - prevent reuptake but no selectivity

17
Q

What are the AE of SSRI and SNRI

A

Gi symptoms: nausea, vomiting, diarrhea, constipation

Serotonin syndrome

18
Q

What are some AE of MAOI

A

Restlessness, irritability, agitation, sleep loss

Adverse food interactions with fermented foods

19
Q

What are some AE with TCA

A 
Sedation
Anticholinergic effects
OH
Arrhythmias 
Seizure
20
Q

Describe the pathophysiology of bipolar disorder

A

Genetic and environmental factors alter neurotransmitters in the brain

Imbalance between inhibitory and excitatory neurotransmitters

21
Q

What is used to treat bipolar disorder and what are some AE

A 
Lithium
AE
 - Not metabolized
 - Danger of accumulation
 - Toxic levels frequently reached
 - Seizures, coma, death

TRI 3 - PH (12 decks)

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