Unit 4 - Wet AMD treatment Flashcards
What is Lucentis?
Humanised antibody fragment that binds to VEGF-A
What is Avastin and how is different to Lucentis?
- Full length monoclonal antiobiody
- Has 2 antigen binding domains c.f. Lucentis which has 1
What is Eylea?
VEGF Trap-eye.
BInds to VEGF and placental growth factor
What is the half-life of avastin?
17-21 days, less than Lucentis
What indications are there to treat when treating on a prn basis?
- Drop in vision >5 letters
- New haem IRF or SRF
When should you consider stopping anti-VEGF according to Royal College?
V/A below 15 letters
or
gone down by 30.
What are the 3 main complications of intravitreals?
- Endophthalmitis
- RPE tears
- Geographic atrophy
GA advances most quickly with which anti-VEGF drug?
Lucentis, quicker than Avastin
At what distance from limbus is the anti-VEGF drug given and why? (phakic and pseudoaphakic)
4mm , 3.5 mm. Through pars plana
How far is needle inserted into eye?
10mm
If patient is less than CF after injection what should be considered?
Paracenthesis to lower IOP
What are the symptoms of endophthalmitis?
Extreme ocular pain
Vision down
Severely injected eye
What is Faricimab?
Anti VEGF A
Anti Ang - 2
What is Brolucizumab?
Beovu
Small single chain antibody fragment designed to inhibit VEGF
What did the FLUID study look at and what were the findings?
Affect of SRF and IRF on vision.
SRF upto 200 microns was tolerated in relaxed group
IRF, lower baseline va, delayed response and poor va outcomes
No statistical change in v/a but relaxed group had less injections
