Unit 4 - CNVM

Question 1

What is the incidence of early AMD according to Beaver Dam study?

Answer 1

14.3%

Question 2

What is the incidence of early and late AMD according to Blue Mountain study?

Answer 2

10.8%
2.8%

Question 3

What are the risk factors of developing AMD?

Answer 3

1. Age
2. Race
3. Smoking
4. CV risks
5. Dietary factors, high fat and obesity
6. Asprin
7. Gender, ? F
8. Cataract surgery?
9. Sunlight exposure?

Question 4

How many nAMD patients develop nAMD in the fellow eye in one year and 4 years?

Answer 4

12%,
27%

Question 5

Which genes are involved in >60% of severe AMD cases?

Answer 5

Complement factor H
Chromosomal 10q26

Question 6

Which other genes are involved in AMD risk?

Answer 6

C2/FB
C1
CFI
APOE

Question 7

What is the risk of developing advanced AMD within 5 years with an AREDS score of4?

Answer 7

50%

Question 8

What factors score a point in the AREDS risk score?

Answer 8

• drusen >125um (one point per eye)
• pigment changes (one point per eye)
• intermediate drusen 63-125 microns in both eyes (one point)

Question 9

What is the type 1,2,3, grading of CNVM based on ?

Answer 9

OCT images

Question 10

What is the occult, classic grading based on?

Answer 10

FFA studies

Question 11

Describe an occult/type1 CNVM lesion?

Answer 11

CNVM under RPE

Question 12

Describe a type 2 cnvm lesion?

Answer 12

above RPE but subretinal

Question 13

Describe a type 3 CNVM lesion?

Answer 13

Retinal angiomatous proliferation lesion starts within retina as a proliferation of retinal capillaries.

Question 14

What type of patient gets RAP?

Answer 14

Older patient

Question 15

What features are there of RAP?

Answer 15

Bilateral
Juxtafoveal
Poor response to anti-VEGF
Poor prognosis

Question 16

What features are there of IPCV?

Answer 16

Peaked PED with srf
Sub retinal haem
OCT very sensitive and specific in detection

Question 17

Which study looked at PDT and Lucentis in IPCV?

Answer 17

Everest (climbing the peaks of IPCV)