Unit 3: Chapter 25 Flashcards
Viruses
- Obligate intracellular parasites
- Cannot reproduce independently
- Can infect all cell types
- Are not living organisms and not composed of cells
why do viruses typically infect only a single tissue type
location of compatible receptors (viruses not infecting random host)
Baceriophages will not infect human because
receptors are not matched
True or False: viruses can have both DNA and RNA
False
Viruses are made of
Comprised of DNA OR RNA surrounded by capsid (protein coat) and/ or envelope derived from a host cell
Virion
Outside the host cell
Have capsid for protection
Capsid
Protein coat for protection outside nucleic acid
Where do viruses get envelopes from?
Arise from plasma or organelle membranes of HOST CELL
In order for viruses to make more progeny, it needs
More virons by more nucleic acids
More capsid by more nucleic acids and protein coat
Why do viruses take over host cell?
To act like living with taking over host metabolism in order to make more progeny
Spike protein
Important in virion attachment to host cell surface
Virus Classification based on:
- Nucleic acid type
- Presence of absence envelope
- Capid symmetry
- Dimensions of Viroid and capsid
Viral mRNA
Original RNA sequence
Positive strand RNA
Same sequence mRNA
Negative strand RNA
Compementary mRNA sequence
A –> U
Negative strand DNA
Complementary DNA sequence
A –> T
Positive strand DNA
Same mRNa with thymine for uracil
Baltimore System of Classification
Organize viruses based on their genome type and the mechanisms used to synthesize mRNA and replicate their genomes
7 Groups of genomes
Lytic cycle
Results in lysis of host cell and destroys host
Virulent phages
Viruses that lyse their host at end of viral life cycle and host cell will be killed
Lysogenic cycle
When phage DNA is incorporated into the host chromosomal DNA
Phase of temperate virus life cycle where it establishes and maintains lysogeny
Does not destroy host cell
Lysogeny
State in which viral genome remains within a cell after infection and reproduces along with it
Does not destroy host cell
Temperate phages go through:
- Lytic cycle: enter host and lyse
- Lysogenic cycle: remain within host without destroying it
- Can also do both with switching from either
Double Stranded DNA viruses (ds DNA viruses)
Largest group of known viruses
Infect all cell types
Only group of viruses that synthesize DNA and RNA
Double Stranded DNA viruses Baltimore System
Genome replication: dsDNA –> dsDNA
Protein synthesis: dsDNA –> mRNA –> Protein
Escherichia virus T4: Virulent bacteriophage
Virulent (lytic) dsDNA phage
Kills host cell immediately
Phage Life cycle culminates with host cell bursting and releasing virion