Unit 2 Cell Membranes and Homeostasis Flashcards
selective permeability
plasma membranes allow some substances to cross more easily than others
phospholipids
the most abundant lipids in most membranes
-amphipathic; have both a hydrophilic and hydrophobic region
fluid mosaic model
membrane is a fluid structure with a “mosaic” of various proteins embedded or attached to a double (bilayer) of phospholipids
The Fluidity Membranes
- membrane is held together mainly by weak hydrophobic interactions
- most lipids and some proteins can shift laterally (this occurs rapidly)
- some proteins seem to be moved and directed by cytoskeleton while others are held in place
- membranes must be within a certain range of fluidity to function properly
The Fluidity of Membranes and Temperature
membranes solidify at low temperatures
- membranes with bent, unsaturated tails will remain fluid at lower temperatures because they cannot be backed closely together
- cholesterol in animal cells resists changes in plasma membrane fluidity caused by change in temperature
integral proteins
penetrate the hydrophobic interior of the lipid bilayer
- hydrophobic part contains stretches of nonpolar amino acids
- hydrophilic parts are exposed to aqueous solutions
peripheral proteins
appendages loosely bound to the surface of a membrane
Functions of Proteins
- Transport
- Enzymatic Activity
- Signal transduction
- Cell-cell recognition
- Intercellular joining
- attachment of cytoskeleton and ECM
Proteins and transport
may provide hydrophilic channel across membrane or shuttle a substance across by changing shape
proteins and enzymatic activity
may be enzyme with active sight exposed to substances in adjacent solution
proteins and signal transduction
may have binding sight that fits the shape of a chemical messenger, protein changes shape and relays message
proteins and cell-cell recognition
some proteins serve as ID tags that are recognized by membrane proteins of other cells
proteins and intercellular joining
membrane proteins of adjacent cells hook together
proteins and attachment of cytoskeleton and ECM
elements of both bound to membrane proteins
The Role of Membrane Carbohydrates in cell-cell recognition
- cells recognize other cells by minding to molecules, often containing carbohydrates, on the extracellular surface of the plasma membrane
- diversity of molecules allow them to serve as markers
glycolipids
carbohydrates bonded to lipids
glycoproteins
carbohydrates bonded to proteins
The permeability of the lipid bilayer
- nonpolar, hydrophobic molecules can dissolve in the lipid bilayer and easily cross the membrane
- polar molecules pass through very slowly
transport proteins
allow hydrophobic substances to pass through
-types: channel proteins and carrier proteins
channel proteins
function by having a hydrophilic channel that certain molecules or ions use as a tunnel through the membrane
aquaporins
allows water to pass through plasma membrane rapidly
carrier proteins
hold on to passengers and shuttle them across the membrane by changing shape
-specific for the substance it transports
passive transport
diffusion of a substance across a membrane with no energy investment
diffusion
the movement of molecules of any substance so that they spread out evenly into the available space
-a substance will naturally diffuse from where it is more concentrated to where it is less concentrated
dynamic equilibrium
reached when molecules cross a membrane at equal rates in both directions
concentration gradient
the region along which the density of a chemical substance increases or decreases