Unit 2 - Cardiovascular System Part 2 Flashcards
myocardial infarction
occurs when there is a complete interruption in blood/O2 delivery to the heart muscle from a blockage in an artery
-result is necrosis (tissue death)
acute MI (AMI)
- typically result of significant CAD that culminates in a complete blockage
- ischemia often a precipitating factor
- often fatal - 30%
transmural
full thickness MI affecting all 3 layers of the heart
nontransmural
partial thickness MI involving sub endocardial layer
most common sites of coronary artery occlusion
- left anterior descending artery (LAD)
- left circumflex artery (LCX)
- right coronary artery (RCA)
STEMI
“ST Elevation Myocardial Infarction”. Typically “transmural” infarctions
~70% of AMI’s are STEMI
non-STEMI
MI that does not demonstrate ST segment elevation on the EKG – Typically “subendocardial” infarctions
pathogenesis
The rupture of a vulnerable atherosclerotic plaque with subsequent thrombus formation, appears to be most common cause of AMI.
“soft” plaques are more likely to rupture than “hard”
diagnosis of MI
- similar to angina but more profound/severe
- chest pain, jaw/neck/shoulder discomfort, dyspnea, overwhelming fatigue
- **may also include nausea and diaphoresis
EKG changes
“injury” pattern is often noted
hallmark characteristic is ST segment elevation (indicator of tissue damage)
Serum enzyme levels
elevations in:
- troponin
- CPK-MB
- LDH “flipped ratio”
- AST
- myoglobin
major complications of MI
Dysrhythmias Heart Failure (HF) Sudden Death Syndrome Mural thrombus / CVA Ventricular aneurysm Ventricular rupture with tamponade
dysrhythmias
Multiple PVC’s - indicates myocardial irritability
Ventricular Tachycardia
Ventricular Fibrillation
requires immediate treatment - medication or defibrillation
heart failure
heart is unable to pump enough blood through the body
causes: decrease myocardial capacity, intrinsic muscle disease, increased BP, valvular disease
sudden death syndrome
death occurring within 1 hour of the onset of cardiac symptoms
in adolescents/young adults under 30, “hypertrophic cardiomyopathy” is most common cause