Uncombable hair syndrome Flashcards
What is Uncombable Hair Syndrome (UHS)?
UHS is a rare genetic disorder causing hair to grow in multiple directions, resulting in a frizzy, dry texture that is difficult to comb.
Which genes are associated with UHS?
UHS is associated with mutations in the PADI3, TGM3, and TCHH genes, which are involved in hair shaft formation.
What are the primary symptoms of UHS?
The primary symptoms include dry, frizzy hair with a silvery or straw-colored sheen that stands out from the scalp and a distinctive triangular or heart-shaped cross-section of the hair strands.
How is UHS diagnosed?
UHS is diagnosed through clinical evaluation and microscopic examination of the hair, which reveals triangular or heart-shaped hair shafts with longitudinal grooves.
What are some conditions that must be differentiated from UHS?
Conditions include Menkes kinky hair syndrome, loose anagen syndrome, and hair damage from physical or chemical treatments.
What treatments are available for UHS?
Treatment is supportive, focusing on gentle hair care practices. Biotin supplements and softening creams or oils may temporarily improve hair texture.
What self-care measures can manage UHS symptoms?
Gentle hair care, using soft brushes, mild shampoos, avoiding heat and harsh chemicals, regular trims, and UV protection are recommended.
How does diet impact UHS?
A balanced diet rich in vitamins and minerals supports overall hair health, although it does not specifically treat UHS.
What is the psychosocial impact of UHS?
UHS can affect self-esteem and social interactions, particularly in school-aged children, making psychological support important.
What is the prognosis for individuals with UHS?
The prognosis is excellent as UHS usually resolves on its own by puberty, with hair texture improving over time.
