ulcerative colitis Flashcards
where does ulcerative colitis affect?
- colon only
- starts at rectum- sigmoid- proximal colon
does ulcerative colitis go through wall?
no
remains in mucosa
- doesn’t go through wall
does ulcerative colitis have skip lesions?
NO
- its continuous
does UC have granulomatous tissue?
NO
what are the goblet cells like in UC?
depleted
describe the crypt abscesses in UC
increased
how is UC diagnosed?
- pANCA positive
- colonoscopy
- biopsy
what would a UC colonoscopy show?
- continuous leadpipe sign
what would a biopsy for UC show?
- mucosal inflammation with crypt hyperplasia
how do you determine the severity of flare?
- truelove and witts scoring
- mild/mod/severe
what are the symptoms for UC?
- LLQ pain
- Tenesmus - rectal infection pain
- Diarrhoea with blood, water and mucus
- extra intestinal symptoms
what are the extra intestinal symptoms for UC?
- Uveitis/ episcleritis
- erythema nodosum
- spondylarthropathy
- PSC- Primary sclerosis cholangitis
what are the complications of UC?
- toxic megacolon
what are the risk factors of UC?
NSAIDS
stress
jewish
smoking protects!!!!
how is UC treated for flares?
sulfasazine + prednisolone
how is UC treated for remission?
azathioprine, methotrexate, lidosporin
how is UC treated with biologics?
anti TNF alpha - infliximab
what are the 4 ways UC is treated ?
- flares
- remission
- biologics
- surgery- CURATIVE
