Type III Hypersensitivity Flashcards
Local type:
immune complexes are formed w/in tissue
Generalized type:
Immune complexes are formed w/in the blood stream. Complexes are deposited in glomeruli in kidney
synovial joint membrane
Signs of local type:
- animal w/ high levels of Ab in blood stream
- inflammation @ injection site
Arthus Reaction
- red edematous swelling, local hemorrhage, thrombosis & tissue destruction
- 6-8 hour rxn
- first neutrophil, then macrophages = nitric oxide, chemokines, leukotrienes and cytokines
Reversed Arthus Reaction
- animals w/ high levels of Ag, then Ab is injected SQ
* activation of complement
Pathogenesis of Arthrus Rxn
antigen in tissues+Antibody
macrophages, neutrophils, mast cells
degranulation
tissue destruction
Local Type examples
- Blue eye (canine adenovirus type-1) bc of vx induces hypersensitivity uveitis
- Hypersensitivity pneumonitis (saccharopolyspora rectivirgula) humid–> fungus on food
- staphyloccocal hypersensitivity
How can you differentiate b/t type I, II, III on a skin lesion?
most common is type III
- measure IgE=type I
- tissue sample, neutrophils more abundant in type III
- increased macrophage is type IV
Generalized type signs:
- most affected: synovial membranes, kidney, arteries
- inflammation is the main rxn
Kupfer cells (liver macrophage) bind to
RBCs and phagocytize
Glomerulonephritis
the structure of a typical glomerulus, immune complexes may be deposited on either side of or within, the glomerular basement membrane
Dz causing Type III hypersensitivity
- constant challenge for animal w/in immune system
- produce a lot of immune complexes
What do type I, II, III hypersensitivity have in common?
humeral immune responses are important
