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RUSVM Immuno exam 2 > Lymphocytes and Co-stimulatory receptors > Flashcards

Lymphocytes and Co-stimulatory receptors Flashcards

1
Q

What type of immune response do T & B cells have?

A

Adaptive

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2
Q

What type of immune response do NK cells have?

A

Innate

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3
Q

Three lymphocytes?

A

NK cells = innate
T cells = cellular
B cells = humoral

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4
Q

Lymphocyte locations?

A

lymphoid organs, bone marrow, lymph nodes, intestine, peyers patches/ spleen, blood

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5
Q

Lymphocytes originate from

A

bone marrow stem cells

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6
Q

T cells from

A

thymus

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7
Q

Plasma cells produce

A

antibodies

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8
Q

B cells are from

A

Bursa

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9
Q

All adaptive immune response starts in the

A

secondary lymphoid organs

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10
Q

Memory B cells

A

recognize antigen & divide in plasma cells

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11
Q

T helper cells that help trigger immune response

A

Th1, 2, 17

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12
Q

Th1 stimulation will trigger

A

cellular immune response

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13
Q

Th2 stimulation will develop

A

antibodies humoral immune response

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14
Q

Th17 stimulation is only

A

humoral but not as important as Th2

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15
Q

Thymus

A
  • T cells
  • Paracortex lymph nodes
  • Periarteriolar lymphoid sheets of spleen
  • interfollicular areas in peyers patches
  • 60-80% lymphocytes in blood
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16
Q

Bone marrow/ Bursa of Fabricus

A
  • B cells
  • Follicles in peyers patchs
  • Cortex of lymph nodes
  • Marginal zone in white pulp of spleen
  • 10-40% lymphocytes in the blood
17
Q

Tolerance

A

lack of immune response

18
Q

Effector T cells

A

cytotoxic T cells to recognize infected cells w/ intracellular pathogens
-works on cancer cells, transplants, skin grafts rejected

19
Q

B cells

A
  • BCR-immunoglobulin
  • immunoglobulins
  • free foreign proteins
  • Difficult tolerance induction
  • Plasma cells, memory cells progeny cells
  • immunoglobulins secreted
20
Q

T cells

A
  • TCR-protein (CD3, CD4, CD8)
  • Processed foreign proteins in MHC antigens
  • easy tolerance induction
  • effector T cells, memory T cells progeny cells
  • Cytokines secreted
21
Q

TCR (T cell antigen receptor) types:

A

TCR α/β

TCR γ/δ

22
Q

BCR (B cell antigen recpetor) types:

A 
BCR α
BCR γ
BCR μ
BCR ε
BCR δ
23
Q

Antibodies and B cell receptors are the same except

A

antibodies are free and B cell receptors are attached to cell membrane

24
Q

What is the main function of T & B cell receptors?

A

to bind/recognize specific antigens

25
Q

CD3

A

present in all T cells

26
Q

CD4

A

present in all Th cells

-receptor for MHC II

27
Q

CD8

A

present in all cytotoxic T cells (Tc)

-receptor for MHC I

28
Q

T cell receptor function?

A

recognize the antigen

29
Q

Transport receptor

A

transferrin CD71

30
Q

Regulatory Receptors (T cells):

A
  • Histamine-H3
  • Immunoglobulins-FcR
  • Complement- CD35, C3b, C4b
  • IL-2 - CD25
  • CD58 - CD2
31
Q

What could be the effects on T cells activation?

A
  • cell division, proliferate
  • cell differentiation
  • macrophages are activated release of cytokines
32
Q

B cell receptors:

A 
Complement receptors (IL-2, 4, 5) 
Antigen receptor (BCR) 
Cytokine receptors (C3b, C4b)
Immunoglobulin receptors (IgM, IgG, IgE)
33
Q

B cell activation effects?

A

produce antibodies, dividing, differentiating plasma Vs memory cells

34
Q

Integrins

A

B1 (integrins, fibronectin, laminin, collagen)

B2 (integrins, intracellular adhesion molecule 1)

35
Q

Selectins in vascular endothelial cells

A

P-selectin
L-selectin
E-selectin

36
Q

Lymphocyte mitogens

A 
Phyytohemagglitinin
Concanavalin
Pokeweed
Lipopolysaccharide
Bacille Calmette-Guerin
Red Kidney Bean
Jackbean 
Gram - bacteria
Mycobacterium
37
Q

Molecules/receptors that can regulate the lymphocyte functions:

A

cytokines, antibodies, compliment, antigen- can all modify behavior of T & B cells

38
Q

CD4 & CD8 are expressed on

A

T cells, NOT B cells

RUSVM Immuno exam 2 (13 decks)

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