Cellular immune response II

Question 1

Interaction b/t T cell and an antigen presenting cell generates the supramolecular structure called

Answer 1

an immunological synapse. Thus a series of concentric rings form around the interacting TCR-MHC complex. These rings contain different co-stimulatory molecules

Question 2

What is the main function of transcription factors inside the cell?

Answer 2

make the RNA (gene expression) using DNA template

-use proteins –> cytokines & IL

Question 3

What is the main function of CD3?

Answer 3

activate cells w/ intracellular signals

Question 4

The more antigens, the

Answer 4

stronger the signal (activation)

-successful stimulation of a T cell requires multiple signals

Question 5

1 MHC + antigen activates

Answer 5

CD8 T cells

Question 6

1000 MHC + antigen activates

Answer 6

CD4 T cells

Question 7

Superantigens do not require MHC antigen presentation bc they have

Answer 7

• powerful T cell response
• high cytokine production
• toxic shock syndrome

Question 8

If we inject a lot of TNF or IL-1, would the animal die?

Answer 8

Yes, toxic shock syndrome

Question 9

Superantigens bind only to the

Answer 9

beta chain

Question 10

CD4 Helper T cells subpopulations:

Answer 10

-Th1-regulates cellular
-Th2-humoral/antibody
Th17

Question 11

Th1

Answer 11

IL-2, IFNγ, TNF-β –> T cell cytotoxicity, macrophage activation, some IgG production
CELLULAR RESPONSE

Question 12

Th2

Answer 12

IL-4, IL-5, IL-10, IL-13 __> Some IgG production, IgA and IgE production
HUMORAL RESPONSE

Question 13

IL-2 & IFNγ inhibit which cells?

Answer 13

Th2 cells

Question 14

Cytokines produced by Th1 cells and their major properties

Answer 14

• IL-2: activates T cells, B cells, NK cells & macrophages
• INF-γ: inhibits Th2 cells, stimulates Th1 cells, activates NK cells and macrophages

Question 15

What is the main function of INFγ?

Answer 15

to stop virus repro

Question 16

The cytokines produced by Th1 cells and their major properties

Answer 16

INFγ

• activates NK cells- enhanced cytotoxicity
• activates macrophages- increase IL-12 production*
• antiviral

Question 17

Functions of IL-2

Answer 17

promotes B cell proliferation & Th1 activation

Question 18

Cytokines produced by Th2 cells?

Answer 18

IL-4, IL-5, IL-9, IL-10, IL-13

Question 19

IL-4 and IL-10 inhibit

Answer 19

Th1 cells so we will have a humoral immune response e/ antibodies

Question 20

Th2 promotes which response?

Answer 20

humoral

Question 21

M1 leads to

Answer 21

inflammation

Question 22

M2 leads to

Answer 22

wound healing and repair

Question 23

γ/δ T cells may act as _____ cells w/ an invariant antigen receptor. Others may act as ____ cells w/ diverse TCRs of polyclonal origin

Answer 23

innate immune cells

classic helper T cells

Question 24

γ/δ T cells: Innate

Answer 24

• found in skin, uterus
• limited TCR diversity recognizing CD1d-associated lipids
• produce IFN-γ and IL-17
• Antigen-presentation to alpha/beta cells

Question 25

γ/δ T cells: Adaptive

Answer 25

• Found in GI tract & secondary lymph organs
• Polyclonal TCRs recognizing multipe antigens
• Th1 subset IFN-γ
• Th2 subset IL-4

Question 26

Naive T cell can divide into

Answer 26

helper T cell precursor (contact pole w/ dendritic cell) or memory T cell precursor

Question 27

Cellular Immune Response is directed to eliminate

Answer 27

cancer cells, intracellular parasites, intracellular bacteria

Question 28

Absence of co-stimulatory signals mediated by the CD3 activation can inhibit/avoid the triggering of the cellular immune response. T/F

Answer 28

TRUE