Type 3 hypersensitivity

Question 1

Type 3 hypersensitivity

Answer 1

allergic reactions involving deposition of immune complexes with the activation of complement- SOLUBLE ANTIGENS

Question 2

type 3 hypersensitivity mechanism

Answer 2

deposition of IgG or IgM IC

Question 3

type 3 hypersensitivity tissue injury mechanism

Answer 3

complement activation and phagocytic activity

Question 4

Arthus reaction

Answer 4

localized reaction caused by immune complexes (aggregates of antigen and antibody)
muscle soreness after intramuscular booster

Question 5

C3a

Answer 5

increased permeability of blood vessels (edema)

Question 6

C5a

Answer 6

attracts neutrophils to size

Question 7

“frustrated phagocytosis”

Answer 7

occurs due to neutrophils attempted to phagocytose immune complexes but cannot due to size of mass - release of array of proteases, collagenases, reactive oxygen intermediates and vasoactive substances

Question 8

Serum sickness syndrome

Answer 8

systemic type 3 hypersensitivity reaction.