Tumor Immunology Flashcards
p53
tumor suppressor protien
dna damage to gene that encodes for p53 is responsible for over 50% of cancer
main theory of tumor immunology
mutations in genes that result in neoplastic cells also lead to changes in expressed proteins - the changed protein should result in recognition of that protein as a “non-self” antigen by the immune system
innate immunity response to tumors
NK cells recognize a lack of self HLA on tumor cells using killer inhibition receptors
IgG alone
in response to tumor cells
opsonization and phagocytosis of tumor cells
IgG and IgM antibody and complement
in response to tumor cells
tumor cell lysis
Monoclonal antibody immunotherapy
monoclonal antibodies specific for surface molecules on tumor cells activate ADCC, opsonization, and phagocytosis
Rituzimab
anti-CD20
target b cells in b cell lymphoma
Her2/neu
monoclonal antibody to target breast and ovarian cancer
Cetruzimab
anti-DGFR
target cancer cells in colorectal, head, and neck cancers
monoclonal antibody immunotherapy
check-point inhibitors
receptor ligand interactions that dictate the amplitude and quality of the immune response
used to amplify the anti-tumor immune response
Anti-CTLA-4 (Ipilimumab)
CTLA-4 -> CD 80 or CD 86
ADCC
antibody-dependent cell mediated cytotoxicity
IFN-gamma
attracts and activates macrophages to the area of antigen
IL-2
activation of CTL and NK
CD 4 T helper cells
release IFN-gamma, IL-2
