Exam 3 Flashcards
Chief cytokines that induce inflammation
IL1, IL6, IL8, TNF-alpha
IL - 1 beta local effects
Activates vascular endothelium, actives lymphocytes, local tissue destruction, increase access of effector cells
TNF - alpha local effects
-activates vascular endothelium and increases vascular permeability which leads to increased entry of IgG complement, and cells to tissues
IL - 6 local effects
Lymphocyte activation and increased antibody production
IL -8 local effects
Chemotactic factorrecruits neutrophils, basophils, and T cells to site of infection.
IL-12 local effects
Activates NK cells
Induces the differentiation of CD4 T cells into TH1 cells
Intramural polio vaccine
Killed/inactive vaccine
Downside to killed or inactived vaccine
Immune response may
IL - 1B systemic effects
fever and production of IL-6
TNF - Alpha systemic effects
fever, mobilization of metabolites, shock
IL- 6 systemic effects
fever and induces acute phase protein by hepatocytes
C-reactive protien
indicator of an acute-phase response in humans for early detection of infections, inflammation, or other diseases associated with tissue injury
Fibrogen
acute phase protein that reduces the charge on erythrocytes to make them more “sticky”
Extravasation steps
- adhesion molecules 2. rolling 3. diapedesis 4. chemotaxis
hallmark of inflammatory response to bacterial infection
higher amounds of PMNs from IL 8 (polymophonuclear lymphocytes like …)
