Type 2 hypersensitivity

Question 1

Type 2 hypersensitivity

Answer 1

ANTIBODY-MEDIATED CYTOTOXIC REACTIONS. allergic reactions involving tissue or cellular antigens and antibodies of IgM or IgG. INSOLUBLE ANTIGEN

Question 2

type 2 hypersensitivity mechanism

Answer 2

IgG or IgM or C3b

Question 3

type 2 hypersensitivity tissue injury

Answer 3

complement activation, phagocytosis, abnormal receptor function

Question 4

ABO system

Answer 4

alloantigens and naturally occurring antibodies

Question 5

isohemaglutinins

Answer 5

IgM antibodies - Anti-A or Anti-B

Question 6

Rh system

Answer 6

no naturally occuring antibodies to Rh antigens, several related antigens with D or Rh-o

Question 7

Rh+ genotype

Answer 7

presence of “D”

Question 8

Rh- genotype

Answer 8

absence of “D” only “d”

Question 9

HDN

Answer 9

hemolytic disease of the new born - Rh incompatibility with child (Rh+) and mother (Rh-. mixing of circulation induce IgG anti-Rh antibodies in mother

Question 10

prevention of RDN

Answer 10

desensitization of Rh factor by administration of RhoGam

Question 11

transfusion reaction

Answer 11

contaminated blood

Question 12

Major hemolytic incompatibility

Answer 12

RBC transfusion - different ABO blood typing - leads to anaphylaxis

Question 13

Minor hemolytic incompatibility

Answer 13

donor serum or plasma contains antibodies angainst the cells

Question 14

Delayed hemolytic reaction

Answer 14

antibodies to donor cells form after transfusion

Question 15

anti-HLA transfusion reaction

Answer 15

antibody to white blood cells