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Farma > Tx de dislipidemia > Flashcards

Tx de dislipidemia Flashcards

1
Q

Estatinas

A

Atorvastatina
Rosuvastatina

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2
Q

MA de estatinas

A

Inhibe HMG-Coa redactada
Disminuyéndomelo síntesis de colesterol
Aumenta R LDL
Forma HDL

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3
Q

Sustrado de HMG-Coa redactada

A

Mebalonato

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4
Q

Indicaciones generales de las estatinas

A

1era linea
Reduction de ECV

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5
Q

Contraindicaciones de estatinas

A

No en embarazo

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6
Q

EA de estatinas

A

Hepatotoxicidad
Rabdomiolisis

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7
Q

Anticuerpos monoclonales

A

Evolocumab
Alirocumab

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8
Q

MA de anticuerpos monoclonales

A

Antagonista de PCSK9
Aumenta recaptura de LDL en plasma
Destruye R LDL

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9
Q

Indicaciones generales de anticuerpos monoclonales

A

Hipercolesterolemia primaria
Se agrega en tx dislipidemia secundaria

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10
Q

EA de anticuerpos monoclonales

A

Reacciones locales
Aumento de enzimás hepaticas

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11
Q

Fibratos

A

gemfibrozilo
Fenofibrato
Bezafibrato

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12
Q

MA de fibratos

A

Agonista PPAR
Aumenta expresiones y actividad LPL
Disminución VLDL

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13
Q

Indicaciones generales de Fibratos

A

Hipertrigliciremia Severa

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14
Q

EA de fibratos

A

Colelitiasis
Rabdomiolisis

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15
Q

MA de Ezetimiba

A

Inhibe absorción de colesterol

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16
Q

MA de Niacina

A

Inhibe lipolisis
Disminución de síntesis de LDL
Aumento de síntesis de HDL

17
Q

MA de Colestiramina

A

Se une a bilis
Impide absorción

18
Q

Indicaciones generales de Ezetimiba

A

Con ESTATINA mayor acción
Cuando estatinas estan contraindicada

19
Q

Indicaciones generales de Niacina

A

Hipertrigliceridemia severa

20
Q

Indicaciones generales de Colestiramina

A

Uso en jovenes
Eficacia limitada

21
Q

Contraindicaciones de ezetimibe

A

No se absorbe

22
Q

Contraindicaciones de Colestiramina

A

No se absorbe

23
Q

EA de ezetimibe

A

Bien tolerada
Aumento de enzimáticos hepatica

24
Q

EA de Niacina

A

Hiperglucemia
Hiperuricemia
Rubor

25
Q

EA de colestiramina

A

Estreñimiento
Calambres

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