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Farma > Antidepresivos > Flashcards

Antidepresivos Flashcards

1
Q

ISRS

A

Sertralina
Citalopram
Fluoxetina

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2
Q

MA de ISRS

A

Inhiben receptores de recaptura de serotonina aumentandonoslas niveles de 5HT en hendidura postsinaptica

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3
Q

Indicaciones Generales de ISRS

A

Depresión mayor
Toc
Ansiedad

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4
Q

Utilidad de ISRS

A

Postmenopausia
Bulimia
Periodo menstrual

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5
Q

EA de ISRS

A

Inhibidor de CYP 450
Sx serotoninergico

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6
Q

Indicaciones generales de Sertralina

A

Px pediatrics y ancianos

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7
Q

EA de citalopram

A

Torsades Pointes
Prolongación de QT

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8
Q

Sintomas de Sx serotoninergico

A

Midriasis
Diaforesis
Taquicardia
Hiperreflexia

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9
Q

IRNS

A

Venlafaxina
Duloxetine

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10
Q

MA de IRNS

A

Inhibicion de receptores de recaptura de serotonina y sodio

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11
Q

Indicaciones generales de IRNS

A

Depression mayor
Dolor neuropatico (duloxetine)

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12
Q

EA de IRNS

A

Similar a ISRS
incremento de FC y TA
Duloxetine: hepatotoxico

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13
Q

ADME de IRNS

A

venlafaxine: no efectos en CYP
Duloxetine: metabolismo extenso e inhibidor de 2D6

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14
Q

Atipicos

A

Mirtazapina
Bupropion

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15
Q

MA de Mirtazapina

A

Antagonista de 5HT2a, 5HT3.
antagonista A1 y H1

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16
Q

MA de bupropion

A

Inhibicion de NET y DAT

17
Q

Indicaciones generales de mirtazapina

A

Depression grave

18
Q

Indicaciones generales de bupropion

A

Depression grave
Suspension de tabaquismo

19
Q

EA de mirtazapina

A

Granulocitopenia

20
Q

EA de Bupropion

A

Aumenta riesgo de convulsiones

21
Q

Triciclicos

A

Amitriptilina
Nortriptilina
Imapramina

22
Q

MA de triciclicos

A

Inhibition de SERT yy NET
antagonismo adrenergico, histaminergico y colinergico

23
Q

Indicaciones generales de Triciclos

A

Depression grave
Dolor neuropatico
Profilaxis migraña

24
Q

EA de triciclicos

A

Nunca de primera linea
Tres Cs
Cardiotoxico
Convulsiones
coma

25
Q

IMAO’S

A

No selectivo: isocarboxasida
Selectivo: selegelina

26
Q

MA de IMAO;S

A

Aumento de 5HT, NA y DA

27
Q

Indicaciones generales de IMAO’S

A

Antiparkinsoneano
Ultima linea de tx depresión

28
Q

EA de IMAO;S

A

Hipotension ortostatica
Sx serotoninergico

29
Q

Interacciones de IMAO;S

A

alimentarias
(queso, embutidos )
Llevan a crisis hypertensiva

30
Q

Antidoto de IMAO’S

A

fentolamina

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