Tumors

Question 1

Answer 1

Fibroma: fibrous and connective tissue tumor

• benign tumors of fibrocytes produced large amounts of collagen
• hari follicles, sebaceous glands(dilated by the surrounding tumor)
• tumor cells: elongated nuclei, which shows strong basophillia
• stroma is made up by collagen CT
• Blue: nuclei of well differentiate elongated neoplastic fibroblasts

Question 2

Answer 2

Fibroma

Question 3

Answer 3

Fibrosarcoma:

= malignant CT tumor of fibroblast

Question 4

Answer 4

Fibrosarcoma:

• see the mitotic figures
• intraluminal blood vessels
• necrosis
• lymphocytes

Question 5

Answer 5

Sarcoma gigantocellulare:

= pleomorphic sarcoma / anaplastic sarcoma with giant cells

• malignant fibrous histocytoma
• vascular intratumoral areas
• multinucleated giant cells
• mitotic figures(metaphase)(anaphase)

Question 6

Answer 6

Haemangioma cavernosum:

=benign tumors of vascular endothelium (blood vessel producing tissue)

• large vascular spaces filled with blood
• very pink material= fibrin
• in between CT = edema/serous infiltration.

*cavernousous(large)

*capillary(small)

• the differences is the size of vascular spaces.
• see mast cells, plasma cells as well

Question 7

Answer 7

Simple adenoma(adenom simplex):

• mature tumor of glandular tissue
• well demarcated
• One cell type( tubular)= so tumor is peri-tubular
• arises from the milk ducts and not from the lobuli
• simple cuboidal
• simple columnar

*neoplastic tubuler are separeted by fibrovascular CT stroma.

Question 8

Answer 8

Simple Adenoma(adenoma simplex).

• look at the cells
• columnar
• cuboidal

Question 9

Answer 9

Adenocarcinoma:

Question 10

Answer 10

Adenocarcinoma:

• in SI( villi) or LI( no villi)
• intact parts of the intestines (Villi, goblet cells, glands/crypts)
• tumoral part( propria glands are like bubles, lack of villi stucture)
• mitotic and apoptoic cells
• lumen filled w/ proliferating cells
• necrosis, polymorphism and hypo-hyper chromatic cells

Question 11

Answer 11

Papilloma (oral mucosa):

• identify . the epidermal hyperplasia
• Ghost cells
• Kilocytes= due to papillomavirus
• mitotic figures
• Inclusion bodies
• Keratocytes
• Finger like processes

Question 12

Answer 12

Papilloma (oral mucosa):

• identify . the epidermal hyperplasia
• Ghost cells
• Kilocytes= due to papillomavirus
• mitotic figures
• Inclusion bodies
• Keratocytes
• Finger like processes

Question 13

Answer 13

Squamous cell carcinoma (skin):

• finger like projections going inwards
• identify dysplastic epidermis(enlarged and broken epidermis w/ inflammatory cells) and hyperkeratosis on top
• hair follicles
• tumor islets and stroma
• keratin pearl in middle (like foreign body) = concentric lamellae of keratin (keratosis)
• outer mitotic cells and outer flattened cells