ALL Flashcards
Adenocarcinoma:
- Villi (small intestines)
- Goblet cells
- Crypts, Glands
- prorpia glands( look like bubbles)
- infiltrate the basal membrane
- Apoptosis
- Necrosis
- Hypo/Hyper-chromatic cells
Adenoma simplex:
- glandular tissue (mammary gl.)
- well demarcated
- nodular /multinodular
- Acini=> different size + arrangements
- simple cuboidal epth
- simple columnar epth
Fibroma:
- benign tumor of fibrocytes
- produce much COLLAGEN FIBERS
- hair follice, sebacous gl dilated due to tumor
.stron basophillic
1) myxoma
2) keloidal
Fibroma:
- benign tumor of fibrocytes
- produce much COLLAGEN FIBERS
- hair follice, sebacous gl dilated due to tumor
.stron basophillic
1) myxoma
2) keloidal
Fibroma:
Fibrosarcoma:
- malignant CT tumor of fibroblast
- spindle shaped fibroblast
- proliferating fibroblast
- coagulation necrosis= due to hypoxia
- hemorrhages
- eosinophillic cytoplasm
- multinucleated GIANT CELLS
- intratumoral vessels
- lymphocytes
!!Feline sarcoma virus (FSV)
!! Vaccine associated
Haemangioma cavernosum:
- Vascular epithelium
- Cavernousus (large)= vesicular spaces divided by CT
- Inflammatory cells
- MAST CELL
- PLASMA CELL
Papilloma:
- cutanous membrane= oral mucosa
- finger like projections covered by Str.squamous epth
- epidermal hyperplasia
- Ghost cell
- KOILOCYTES
- mitotic figures
- Inclusion bodies
Sarcoma gigantocellulare:
- tumor of CT
- multinuclear GIANT CELLS
- Apoptosis= regressive changes
- Metastastis to lungs
!! Vaccine associated
Sarcoma gigantocellulare:
- tumor of CT
- multinuclear GIANT CELLS
- Apoptosis= regressive changes
- Metastastis to lungs
!! Vaccine associated
Squamous cell carcinoma:
- skin, epidermis, hairfollicles
- finger like projections??
- dysplastic epidermis=> HYPERKERATOSIS
- inflammatory cells
- neutrophills
- mitotic cells
- KERATIN PEARLS
- squamous epithelium
Cholangiohepatitis:
- lobular structures=>portal area
- inflamation/infiltration aroud the bilde duct
- lymhocytes
- neutrophils
- histocytes
- plasma cell
- dilated vessels
suppurative inflammation??
- necrotic area
- CT proliferation
!! Salmonella
!! Campylobacter
!!Coccidosis
Cholangiohepatitis:
- lobular structures=>portal area
- inflamation/infiltration aroud the bilde duct
- lymhocytes
- neutrophils
- histocytes
- plasma cell
- dilated vessels
suppurative inflammation??
- necrotic area
- CT proliferation
!! Salmonella
!! Campylobacter
!!Coccidosis
Liver cirrhosis:
- necrosis of hepatocytes
- CT proliferation
- Fibrosis
- Extensive interlobular CT proliferation
- Pseudo-lobules( ø Central vein inside)
- Ductal proliferation
Ø inflammatory cells
Rubarth disease: infectious canine hepatitis
*dystrophic triad
- lobules, porta, hepatocytes
- centerolobular necrosis
- Sinusoids/DISSE filled with RBC + serum
- Councilman bodies= Apoptotic hepatocytes
- Cowdry A inclusion bodies
- Portal + sinusoidal inflammation of “DISSE” spaces
- inflammatory cells around the hepatocytes
!! Canine adenomvirus-1
Acute leptomengitits: Glasser disease
- brain tissue
- Dilated blood vessel
- GLIAL cells= brain macrophages
- Inflammatory cells (Lymphocytes, Histocytes, Neutrophils, Plasma cells)
- Eosinophil granulocytes
- Microabscess= purulent
!! Haemophillus parasuis
Acute leptomengitis: Glasser disease
- inflammatory cells infiltrate the brain tissue
Acute leptomengitis:
Encephalitits caused by Listeria monocytogenes:
- perovascular inflammatory cell infiltration
- Dilated blood vessel filled with RBC
- Destroyed motor neuron
- Granular glial cells-> abscess of glial cells and neutrophils
- Ring shaped accumulation of inflammatory cells around the blood vessel
- Histocytes
- Lymphocytes
- Neutrophils
Paratuberculosis enteritis: John´s disease
- small intestines(Villi structure)
- Goblet cells
- proliferation of epithelial cells
- Langhans cells (Giant cells) in necrotized mm.
- Eosinophils
- Neutrophils
- Histocytes
- Crypts
!! Mycobacterium avium ssp paratuberculosis
Paratuberculosis enteritis: Johne´s disease
Parvoviral enteritis:
- necrotizing enteritis
- small intestines(Villi structure)
- Atrophied villi–>loss of structure
- Damaged crypts
- Remnants of Liberkuhn crypts
- Inflammatory cells
- mitotic figures
- Blunt Villi
!! Canine parvovirus-2
West-Nile:
- dead neuron surrounded by Gial cells
- neurons are degenerated or destructed due to virus
- Astrocytes appear around them
- GLIAL cell proliferation
- Lymphocytes=> dark spots (ø Neutrophils)
!!Flavivirus by mosquitos
West-Nile:
Encephalitis by Listeria:
- Dilated blood vessel filled with RBC
- Ringh shaped accumulation of inflammatory cells around the blood vessel
- Histocytes
- Lymphocytes
- Neutrophils
- Destroyed motor neuron
- Granular GLIAL cells
++ abscess of glial cells
-Virscow robin spaces
West-Nile:
-glial scars
Actinobacillus pleuropneumonia:
- serous hemorrhagic necrotic pneumonia
- lung structure (alveoli, bronchi)
- Hyperaemia
- Alveolar edema
- macrophage proliferation
- necrosis + demarcation zone
!! Actinobacillus
Serous desquamative bronchopneumonia:???
- lung tissue structure
- Bronchitis, peribronchitis
- Bronchitis obliterans
- Desquamated type 2 pneumocyte
- Desquamated alveolar
- Chronic demarcation areas
- Serous exudate
!! Mycoplasma
!!Pasturella
!!Streptococcus
Serous desquamative bronchopneumonia:
Serous desquamative bronchopneumonia:??
Fibrinous Croupus pneumonia:
- fibrin in airway
- lung tissue, hard to see du to all the fibrin
- Fibrin rich exudate in alveoli/bronchi
- Hyperaemia=>dilated blood vessel
- Thrombosis of lymph vessel
1) stage congestion–fibrin
2) stage hepatization= RBC colour changes
Fibrinous Croupous pneumonia:
Chronic glomerulonephritis:
-Glomerulus is cell rich due to MESANGIAL cell proliferation and lead to enlargement
—>Segmantend glomerulus
- Capsule thickened= CT proliferation
- Enlarged and shrunken glomerular structure
- Mesangial cell proliferation + lobulation of glomerulus
- Plasma accumulation inside thickened capsule
- protein rich exudate in tubules
*subacute: exudate in glomerulis
*chronic: exudate in tubules
!!Systemic lupus erythro (SLE)
!!Amyloidosis–protein accumulation??
Interstitial pneumonia:
- lung tissue (alvoli, bronchi)
- Atelectasis= closed/collapsed bronchi
- Inflammatory cell proliferation
- Lymphocytes
- Neutrophils
!! lung worm cat
!! toxic gases
!! influenza, distemper, herpes
!! Salmonella
!! Sterptococcus
Interstitial nephritis:
- look like “ant egg”
- Glomerular structure
- Inflammatory cell infiltraion around capsule
- Lymphocytes
- Neutrophills
- Histocytes
- Plasma cells
!! Leptospirosis
!! Mycobacteria
Interstitial nephritis:
Kidney fibrosis:
- collagen fibers
- collagen connective tissue proliferates and replace damaged tubules + glomerulus
- pink fluid inside capsule= fibrin
- Bowmans capsule thickened
- Hyaline like exudates
- Inflammatory cells becouse fibrosis is usaully a consequence of previous kidney damage
Oxalate nephrosis:
Fibrinous Croupous inflammation:
- small intestines (Villi structure)
- mucous membranes covered by fibrin (stomach content moving)
- fibrin at the outerlayer( serosa)
- DEsquamated epthelial cells in fibrin strands
- Fibrin accumulation cause Blunt villi
- Lymphoplasmocytic propria infiltraion–>lymphocytes infiltrate the propria layer
- Plasma cells
- Neutrophils
Adenocarcinoma:
- Small intestines(Villi)
- Arise from columnar epithelium of mm..
- Villi
- Goblet cells
- Crypts/Glands
- propria glands are like “bubbles”= ø villi structure
- break through the basal membrane–> infliltrate deeper
- Apoptosis
- Necrosis
- Hypo/Hyper-chromatic cells
Diffuse purulent inflammation:
- subcutis, hairfollicles, adipocytes
- Connective tissue is loosened
- Diffuse ( no capsule)
- purulent exudates
==Neutrophils
- Hemostasis-> edema, dilated blood vessel
- hyperaemic tissue(RBC)
- collagenolysis
- microvascular thrombus= DIC
- histocytes
- plasma cells
- lymphocytes
- neutrophils
!! Pyogenic bacteria
- staph
- sterpt
- arcano
- pasturella
Fibroma:
- benign tumor of fibrocytes
- Fibrocytes
- prod huge amout of collagen (CT)
- hair follicle, subcutis, sebacous gl, adipocytes
- strong basophillic
*Van Gieson
1) myxoma
2) keloidal
Fibrosarcoma:
- malignant tumor of fibroblast
- spindle shaped fibroblast
- proliferating fibroblast
- COAGULATION necrosis=due to hypoxia
- hemorrhages
- eosinophillic cytoplasm= hypochromatic..
- multinucleated GIANT CELL
- lymphocytes
- necrotize
- intratumoral vessel
!! Feline sarcoma virus (FSV)
!! Vaccine associated
Haemorrhagic inflammation:
- small intestine(Villi structure)
- large hemorrhages= dilated blood vessel (RBC)
- RBC in lumen
- inflammatory cells between the RBC´s
- Lymphocytes
- Neutrophills
- Plasma cells
- proprial layer is EXTRAVASATED WITH RBC
!! Parvovirus
!! E.coli
!! Salmonella
!! Stress
Malignant lymphoma:
- blood cancer
- immature cell stages of lymphocytes
- proprial layer and mucosa are infiltrated by lymphocytes
- malignant= cell polymorphis + mitotic figures
- GRANULOMA formation = histocytes/macrophages
- Apoptosis
- Dilated blood vessel
Malignant lymphoma:
Mastocytoma:
- mast cell tumor
- subcutis, adipose, hair follicles
- Eosinophillic granulocytes among mast cells
- tumor grows into dermis
- collagenolysis
- Basophil granulocytes= round cell
- mitotic figures
*giesma
Mastocytoma:
Melanom malignum:
- heterogenicity (different)
- neuroectodermal orgin= horse
- melanocytic HYPERPLASIA
- Oligopigmented region
- Ameloic melanoma region= dividing cells
- stratified keratinized squamous epithelium
- stroma
- mitotic figures
Benign mixed tumor:
- common in glandular tissue
- Adenoma ( acinar cells)= tubules, with CT between
- Chondroma
- Osteoma
- MYOEPITHELIUM
- strom with CT
- mitotic figures
Benign trichoblastoma:
- basal cell tumor
- Germinative cells of squamous epithelium
- Basophillic nucleus(strong stained)
- MEDUZOID pattern
- hyperchromatic cells
- Capsule= benign
- follicles
- Stroma
*Trichoblast= stem cells of follicles
Benign trichoblastoma:
-meduzoid pattern
