ALL Flashcards

1
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A

Adenocarcinoma:

  • Villi (small intestines)
  • Goblet cells
  • Crypts, Glands
  • prorpia glands( look like bubbles)
  • infiltrate the basal membrane
  • Apoptosis
  • Necrosis
  • Hypo/Hyper-chromatic cells
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2
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Adenoma simplex:

  • glandular tissue (mammary gl.)
  • well demarcated
  • nodular /multinodular
  • Acini=> different size + arrangements
  • simple cuboidal epth
  • simple columnar epth
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3
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Fibroma:

  • benign tumor of fibrocytes
  • produce much COLLAGEN FIBERS
  • hair follice, sebacous gl dilated due to tumor

.stron basophillic

1) myxoma
2) keloidal

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4
Q
A

Fibroma:

  • benign tumor of fibrocytes
  • produce much COLLAGEN FIBERS
  • hair follice, sebacous gl dilated due to tumor

.stron basophillic

1) myxoma
2) keloidal

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5
Q
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Fibroma:

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6
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Fibrosarcoma:

  • malignant CT tumor of fibroblast
  • spindle shaped fibroblast
  • proliferating fibroblast
  • coagulation necrosis= due to hypoxia
  • hemorrhages
  • eosinophillic cytoplasm
  • multinucleated GIANT CELLS
  • intratumoral vessels
  • lymphocytes

!!Feline sarcoma virus (FSV)

!! Vaccine associated

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7
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Haemangioma cavernosum:

  • Vascular epithelium
  • Cavernousus (large)= vesicular spaces divided by CT
  • Inflammatory cells
  • MAST CELL
  • PLASMA CELL
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8
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Papilloma:

  • cutanous membrane= oral mucosa
  • finger like projections covered by Str.squamous epth
  • epidermal hyperplasia
  • Ghost cell
  • KOILOCYTES
  • mitotic figures
  • Inclusion bodies
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9
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Sarcoma gigantocellulare:

  • tumor of CT
  • multinuclear GIANT CELLS
  • Apoptosis= regressive changes
  • Metastastis to lungs

!! Vaccine associated

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10
Q
A

Sarcoma gigantocellulare:

  • tumor of CT
  • multinuclear GIANT CELLS
  • Apoptosis= regressive changes
  • Metastastis to lungs

!! Vaccine associated

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11
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Squamous cell carcinoma:

  • skin, epidermis, hairfollicles
  • finger like projections??
  • dysplastic epidermis=> HYPERKERATOSIS
  • inflammatory cells
  • neutrophills
  • mitotic cells
  • KERATIN PEARLS
  • squamous epithelium
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12
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Cholangiohepatitis:

  • lobular structures=>portal area
  • inflamation/infiltration aroud the bilde duct
  • lymhocytes
  • neutrophils
  • histocytes
  • plasma cell
  • dilated vessels

suppurative inflammation??

  • necrotic area
  • CT proliferation

!! Salmonella

!! Campylobacter

!!Coccidosis

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13
Q
A

Cholangiohepatitis:

  • lobular structures=>portal area
  • inflamation/infiltration aroud the bilde duct
  • lymhocytes
  • neutrophils
  • histocytes
  • plasma cell
  • dilated vessels

suppurative inflammation??

  • necrotic area
  • CT proliferation

!! Salmonella

!! Campylobacter

!!Coccidosis

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14
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Liver cirrhosis:

  • necrosis of hepatocytes
  • CT proliferation
  • Fibrosis
  • Extensive interlobular CT proliferation
  • Pseudo-lobules( ø Central vein inside)
  • Ductal proliferation

Ø inflammatory cells

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15
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Rubarth disease: infectious canine hepatitis

*dystrophic triad

  • lobules, porta, hepatocytes
  • centerolobular necrosis
  • Sinusoids/DISSE filled with RBC + serum
  • Councilman bodies= Apoptotic hepatocytes
  • Cowdry A inclusion bodies
  • Portal + sinusoidal inflammation of “DISSE” spaces
  • inflammatory cells around the hepatocytes

!! Canine adenomvirus-1

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16
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Acute leptomengitits: Glasser disease

  • brain tissue
  • Dilated blood vessel
  • GLIAL cells= brain macrophages
  • Inflammatory cells (Lymphocytes, Histocytes, Neutrophils, Plasma cells)
  • Eosinophil granulocytes
  • Microabscess= purulent

!! Haemophillus parasuis

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17
Q
A

Acute leptomengitis: Glasser disease

  • inflammatory cells infiltrate the brain tissue
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18
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A

Acute leptomengitis:

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19
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Encephalitits caused by Listeria monocytogenes:

  • perovascular inflammatory cell infiltration
  • Dilated blood vessel filled with RBC
  • Destroyed motor neuron
  • Granular glial cells-> abscess of glial cells and neutrophils
  • Ring shaped accumulation of inflammatory cells around the blood vessel
  • Histocytes
  • Lymphocytes
  • Neutrophils
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20
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Paratuberculosis enteritis: John´s disease

  • small intestines(Villi structure)
  • Goblet cells
  • proliferation of epithelial cells
  • Langhans cells (Giant cells) in necrotized mm.
  • Eosinophils
  • Neutrophils
  • Histocytes
  • Crypts

!! Mycobacterium avium ssp paratuberculosis

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21
Q
A

Paratuberculosis enteritis: Johne´s disease

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22
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Parvoviral enteritis:

  • necrotizing enteritis
  • small intestines(Villi structure)
  • Atrophied villi–>loss of structure
  • Damaged crypts
  • Remnants of Liberkuhn crypts
  • Inflammatory cells
  • mitotic figures
  • Blunt Villi

!! Canine parvovirus-2

23
Q
A

West-Nile:

  • dead neuron surrounded by Gial cells
  • neurons are degenerated or destructed due to virus
  • Astrocytes appear around them
  • GLIAL cell proliferation
  • Lymphocytes=> dark spots (ø Neutrophils)

!!Flavivirus by mosquitos

24
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A

West-Nile:

25
Encephalitis by Listeria: ## Footnote - Dilated blood vessel filled with RBC - Ringh shaped accumulation of inflammatory cells around the blood vessel - Histocytes - Lymphocytes - Neutrophils - Destroyed motor neuron - Granular GLIAL cells ++ abscess of glial cells -Virscow robin spaces
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West-Nile: -glial scars
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Actinobacillus pleuropneumonia: ## Footnote - serous hemorrhagic necrotic pneumonia - lung structure (alveoli, bronchi) - Hyperaemia - Alveolar edema - macrophage proliferation - necrosis + demarcation zone !! Actinobacillus
28
Serous desquamative bronchopneumonia:??? - lung tissue structure - Bronchitis, peribronchitis - Bronchitis obliterans - Desquamated type 2 pneumocyte - Desquamated alveolar - Chronic demarcation areas - Serous exudate !! Mycoplasma !!Pasturella !!Streptococcus
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Serous desquamative bronchopneumonia:
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Serous desquamative bronchopneumonia:??
31
Fibrinous Croupus pneumonia: - fibrin in airway - lung tissue, hard to see du to all the fibrin - Fibrin rich exudate in alveoli/bronchi - Hyperaemia=\>dilated blood vessel - Thrombosis of lymph vessel 1) stage congestion--fibrin 2) stage hepatization= RBC colour changes
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Fibrinous Croupous pneumonia:
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Chronic glomerulonephritis: -Glomerulus is cell rich due to MESANGIAL cell proliferation and lead to enlargement ---\>Segmantend glomerulus - Capsule thickened= CT proliferation - Enlarged and shrunken glomerular structure - Mesangial cell proliferation + lobulation of glomerulus - Plasma accumulation inside thickened capsule - protein rich exudate in tubules \*subacute: exudate in glomerulis \*chronic: exudate in tubules !!Systemic lupus erythro (SLE) !!Amyloidosis--protein accumulation??
34
Interstitial pneumonia: - lung tissue (alvoli, bronchi) - Atelectasis= closed/collapsed bronchi - Inflammatory cell proliferation - Lymphocytes - Neutrophils !! lung worm cat !! toxic gases !! influenza, distemper, herpes !! Salmonella !! Sterptococcus
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Interstitial nephritis: - look like "ant egg" - Glomerular structure - Inflammatory cell infiltraion around capsule - Lymphocytes - Neutrophills - Histocytes - Plasma cells !! Leptospirosis !! Mycobacteria
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Interstitial nephritis:
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Kidney fibrosis: - collagen fibers - collagen connective tissue proliferates and replace damaged tubules + glomerulus - pink fluid inside capsule= fibrin - Bowmans capsule thickened - Hyaline like exudates - Inflammatory cells becouse fibrosis is usaully a consequence of previous kidney damage
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Oxalate nephrosis:
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Fibrinous Croupous inflammation: ## Footnote - small intestines (Villi structure) - mucous membranes covered by fibrin (stomach content moving) - fibrin at the outerlayer( serosa) - DEsquamated epthelial cells in fibrin strands - Fibrin accumulation cause Blunt villi - Lymphoplasmocytic propria infiltraion--\>lymphocytes infiltrate the propria layer - Plasma cells - Neutrophils
40
Adenocarcinoma: ## Footnote - Small intestines(Villi) - Arise from columnar epithelium of mm.. - Villi - Goblet cells - Crypts/Glands - propria glands are like "bubbles"= ø villi structure - break through the basal membrane--\> infliltrate deeper - Apoptosis - Necrosis - Hypo/Hyper-chromatic cells
41
Diffuse purulent inflammation: - subcutis, hairfollicles, adipocytes - Connective tissue is loosened - Diffuse ( no capsule) - purulent exudates ==Neutrophils - Hemostasis-\> edema, dilated blood vessel - hyperaemic tissue(RBC) - collagenolysis - microvascular thrombus= DIC - histocytes - plasma cells - lymphocytes - neutrophils !! Pyogenic bacteria - staph - sterpt - arcano - pasturella
42
Fibroma: ## Footnote - benign tumor of fibrocytes - Fibrocytes - prod huge amout of collagen (CT) - hair follicle, subcutis, sebacous gl, adipocytes - strong basophillic \*Van Gieson 1) myxoma 2) keloidal
43
Fibrosarcoma: - malignant tumor of fibroblast - spindle shaped fibroblast - proliferating fibroblast - COAGULATION necrosis=due to hypoxia - hemorrhages - eosinophillic cytoplasm= hypochromatic.. - multinucleated GIANT CELL - lymphocytes - necrotize - intratumoral vessel !! Feline sarcoma virus (FSV) !! Vaccine associated
44
Haemorrhagic inflammation: - small intestine(Villi structure) - large hemorrhages= dilated blood vessel (RBC) - RBC in lumen - inflammatory cells between the RBC´s - Lymphocytes - Neutrophills - Plasma cells - proprial layer is EXTRAVASATED WITH RBC !! Parvovirus !! E.coli !! Salmonella !! Stress
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Malignant lymphoma: ## Footnote - blood cancer - immature cell stages of lymphocytes - proprial layer and mucosa are infiltrated by lymphocytes - malignant= cell polymorphis + mitotic figures - GRANULOMA formation = histocytes/macrophages - Apoptosis - Dilated blood vessel
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Malignant lymphoma:
47
Mastocytoma: ## Footnote - mast cell tumor - subcutis, adipose, hair follicles - Eosinophillic granulocytes among mast cells - tumor grows into dermis - collagenolysis - Basophil granulocytes= round cell - mitotic figures \*giesma
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Mastocytoma:
49
Melanom malignum: ## Footnote - heterogenicity (different) - neuroectodermal orgin= horse - melanocytic HYPERPLASIA - Oligopigmented region - Ameloic melanoma region= dividing cells - stratified keratinized squamous epithelium - stroma - mitotic figures
50
Benign mixed tumor: ## Footnote - common in glandular tissue - Adenoma ( acinar cells)= tubules, with CT between - Chondroma - Osteoma - MYOEPITHELIUM - strom with CT - mitotic figures
51
Benign trichoblastoma: ## Footnote - basal cell tumor - Germinative cells of squamous epithelium - Basophillic nucleus(strong stained) - MEDUZOID pattern - hyperchromatic cells - Capsule= benign - follicles - Stroma \*Trichoblast= stem cells of follicles
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Benign trichoblastoma: -meduzoid pattern
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