Tumor Suppressors

Question 1

APC

Answer 1

negative regulator of beta-catenin/WNT pathway; colorectal cancer (a/w FAP)

Question 2

BRCA1/BRCA2

Answer 2

BRCA1/2 proteins; breast, ovarian, prostate, pancreatic cancers

Question 3

CDKN2A

Answer 3

p16; blocks G1>S phase; many cancers

Question 4

DCC

Answer 4

Deleted in Colorectal Cancer

Question 5

SMAD4 (DPC4)

Answer 5

Deleted in Pancreatic Cancer; pancreatic and colorectal cancer

Question 6

MEN1

Answer 6

Menin; MEN type 1

Question 7

NF1

Answer 7

neurofibromin (Ras GTPase activating protein); NF type 1

Question 8

NF2

Answer 8

Merlin (schwannomin) protein; NF type 2

Question 9

PTEN

Answer 9

negative regulator of P13K/AKT path; Prostate, breasT, ENdometrial cancers

Question 10

RB1

Answer 10

inhibits EF2; blocks G1>S phase; Retinoblastoma, osteosarcoma (Bone cancer)

Question 11

TP53

Answer 11

p53, activates p21, blocks G1>S phase; most cancers, Li-Fraumeni (multiple malignancies at early age, AKA SBLA syndrome for Sarcoma, Breast, Leukemia, Adrenal gland)

Question 12

TSC1

Answer 12

Hamartin protein; tuberous sclerosis

Question 13

TSC2

Answer 13

tuberin (2berin); tuberous sclerosis

Question 14

VHL

Answer 14

inhibits hypoxia-inducible factor 1a; Von Hippel-Lindau

Question 15

WT1

Answer 15

urogenital development TF; Wilms Tumor (nephroblastoma)