Antibodies

Question 1

anti-postsynaptic ACh receptor

Answer 1

Myasthenia gravis

Question 2

anti-presynaptic voltage-gated calcium channel

Answer 2

LEMS

Question 3

antiphospholipid

Answer 3

anti-beta2 glycoprotein 1, anticardiolipin

Question 4

SLE

Answer 4

ANA (nonspecific often a/w), anticardiolipin, anti-dsDNA, anti-Smith

Question 5

antihistone

Answer 5

drug induced lupus

Question 6

anti-U1 RNP

Answer 6

mixed CT disease

Question 7

RA

Answer 7

RF (IgM antibody against IgG), anti-CCP (more specific)

Question 8

anti-Ro/SSA, anti-La/SSB

Answer 8

Sjogren

Question 9

anti-Scl70 (anti-DNA topoisomerase I)

Answer 9

scleroderma (diffuse)

Question 10

anticentromere

Answer 10

CREST

Question 11

anti-synthetase (anti-Jo1), anti-SRP, anti-helicase (anti-Mi-2)

Answer 11

polymyositis, dermatomyositis

Question 12

antimitochondrial

Answer 12

primary biliary cholangitis

Question 13

anti-smooth muscle, anti-liver/kidney microsomal-1

Answer 13

autoimmune hepatitis

Question 14

MPO-ANCA/p-ANCA

Answer 14

microscopic polyangiitis, eosinophilic granulomatosis w/ polyangiitis, UC, primary sclerosing cholangiitis

Question 15

PR3-ANCA/c-ANCA

Answer 15

granulomatosis w/ polyangiitis

Question 16

anti-phospholipase A2 receptor

Answer 16

primary membranous nephropathy

Question 17

anti-hemidesmosome

Answer 17

bullous pemphigoid

Question 18

anti-desmoglein (anti-desmosome)

Answer 18

pemphigus vulgaris

Question 19

antithyroglobulin, antithyroid peroxidase

Answer 19

Hashimoto thyroiditis

Question 20

anti-TSH receptor

Answer 20

Graves

Question 21

IgA anti-endomysial, IgA anti-tissue transglutaminase (TTG), IgA and IgG deamidated gliadin peptide

Answer 21

Celiac

Question 22

anti-glutamic acid decarboxylase, islet cell cytoplasmic antibodies

Answer 22

T1DM

Question 23

antiparietal cell, anti-IF

Answer 23

pernicious anemia

Question 24

anti-GBM

Answer 24

Goodpasture