Tumor Suppressor Genes

Question 1

APC

Answer 1

Negative regulator of beta catenin/ WNT pathway
Colorectal ca
Associated with FAP

Question 2

BRCA1/ BRCA2

Answer 2

DNA repair protein

Breast/ ovarian/ pancreatic ca

Question 3

CDKN2A

Answer 3

p16 blocks G1to S
Melanoma
Pancreatic ca

Question 4

DCC

Answer 4

deleted in colon ca

Question 5

DPC4/SMAD4

Answer 5

Deleted in pancreatic ca

Pancreatic ca

Question 6

MEN1

Answer 6

Menin

Question 7

NF1

Answer 7

Neurofibromin

RAS GTPase activating protein

Question 8

NF2

Answer 8

Merlin
Schwannomin
NF2

Question 9

PTEN

Answer 9

Tyrosine phosphatase of PIP3
Protein kinase B(AKT)activation
Breast ca
Prostate ca
Endometrial ca

Question 10

Rb

Answer 10

Inhibit E2f
Blocks G1 to S
Retinoblastoma
Osteosarcoma

Question 11

TP53

Answer 11

P 53
Activates p21
Blocks G1 to S phase
Most human cancers, li fraumani syndrome 
Sarcoma
Breast
Leukemia 
Adrenal gland

Question 12

Tsc1

Answer 12

Hamartin

Tuberous sclerosis

Question 13

TSC2

Answer 13

Tuberin protein

Tuberous sclerosis

Question 14

VHL

Answer 14

Inhibits hypoxia inducible factor 1a

VHL disease

Question 15

WT1

Answer 15

Transcription factor that regulates urogenital development

Wilms tumor/ nephroblastoma