Adenoma Carcinoma CRC

Question 1

Adenoma carcinoma sequence

Answer 1

APC (adenomatous polyposis coli gene) - sporadic or germline
increases risk of polyp formation
APC inactivates B-catenin (b-catenin increases Cyclin D transcription and progresses cell cycle)
K-ras
leads to formation of polyp
K-ras works in RAS pathway. One function in increase Cyclin D transcription
P53 mutation and increased COX expression
Progression of adenoma to carcinoma
P53 transcription factor of p21; prolonged activation causes transcription of Bax and lead to apoptosis