Diuretics Flashcards
1
Q
Acetazolamide
A
Inhibition of carbonic anhydrase in PCT
↑ Na+ ↑K+
↑↑ HCO3–
Acidosis
2
Q
Loop diuretics
A
Ethacrynic acid, furosemide, torsemide
Inhibition of Na+/K+/2Cl– cotransporter in TAL
↑↑ Na+ ↑K+
↑ Ca2+ ↑ Mg2+
Alkalosis
Increased Cl-
3
Q
Thiazides
A
Hydrochlorothiazide, indapamide, chlorthalidone
Inhibition of Na+/Cl– cotransporter in DCT
↑ Na+ ↑K+
↑ Cl– ↓ Ca2+
Alkalosis
4
Q
k+ sparing
A
Amiloride, triamterene, spironolactone, eplerenone
Block Na+ channels, block aldosterone receptors in collecting tubule
↑ Na+ (small) ↓K+
Acidosis
5
Q
Liddle syndrome
A
Enac receptors
Amiloride
Triamterene
