Pharma

Question 1

M1 and M3

Answer 1

Gq coupled
↑ phospholipase C →↑ IP3, DAG, Ca2+

Question 2

M2

Answer 2

Gi inhibit cAMP

Decrease adenyl cyclase

Question 3

M2

Answer 3

Gi coupled
↓ adenylyl cyclase →↓ cAMP

Question 4

Cholinergics

Answer 4

Direct activators: bethanechol (M), methacholine (M and N), nicotine (N),
pilocarpine (M), cevimeline (M)

Question 5

ACh E Inhibitors

Reversible

Answer 5

edrophonium, physostigmine, neostigmine, pyridostigmine, donepezil, rivastigmine

Question 6

AChE inhibitors: irreversible

Answer 6

malathion, parathion

Question 7

Cholinergic receptor antagonist

Answer 7

Muscarinic blockers: atropine, benztropine, ipratropium, scopolamine
Ganglionic blockers: hexamethonium, mecamylamine

Question 8

Alpha 1 agonist

Answer 8

phenylephrine

Question 9

Alpha2 agonist

Answer 9

clonidine, methyldopa

Question 10

Beta agonist

Answer 10

isoproterenol, (β1 = β2), dobutamine (β1 > β2)
β2 agonists: albuterol, terbutaline, salmeterol

Question 11

Beta2 agonist

Answer 11

albuterol, terbutaline, salmeterol

Question 12

Mixed

Answer 12

Mixed: dopamine (D1, β1, α1), epinephrine (α1, α2, β1, β2), norepinephrine (α1, α2, β1)
Indirect-acting: amphetamine, cocaine, ephedrine, tyramine