Tumor Suppressor Genes Flashcards
1
Q
APC
A
colorectal cancer (associated with FAP)
2
Q
BRAC1/BRAC2
A
DNA repair protein
Breast and ovarian cancer
3
Q
DCC
A
colon cancer
4
Q
DPC4/SMAD4
A
pancreatic cancer
5
Q
MEN1
A
menin
MEN1
6
Q
NF1
A
Ras GTPase activating protein (neurofibromin)
Neurofibromatosis type 1
7
Q
NF2
A
Merlin (schwannomin) protein
NeuroFibromatosis type 2
8
Q
p16
A
cyclin-dependent kinase inhibitor 2A
Melanoma
9
Q
p53
A
bascially a bitch
transcription factor for p21, blocks G1-S phase
most human cancers
Li-Fraumeni syndrome
10
Q
PTEN
A
breast, prostate, endometrial cancers
11
Q
Rb
A
inhibits E2F; blocks G1-S phase
retinoblastoma
osteosarcoma
12
Q
TSC1
A
hamartin protein
tuberous sclerosis
13
Q
TSC2
A
Tuberin protein
tuberous sclerosis
14
Q
VHL
A
inhibits hypoxia inducile factor 1a von Hippel-Lindau disease renal cell carcinoma cerebellar hemangioblastoma retinal hemangioma liver cyst located on chromosome 3
15
Q
WT1/WT2
A
wilms tumor (nephroblastoma)
