Paraneoplastic Syndrome

Question 1

1,25-(OH)2 D3 (calcitriol)

Answer 1

leads to Hypercalcemia

due to Hodgkin lymphoma, non-Hodgkin lymphoma

Question 2

ACTH

Answer 2

leads to cushing syndrome

due to small cell lung carcinoma, renal cell carcinoma

Question 3

ADH

Answer 3

leads to SIADH

due to small cell lung carcinoma, intracranial neoplasms

Question 4

Antibodies against presynaptic Ca channels at NMJ

Answer 4

leads to Lambert-Eaton mysthenic syndrome (muscle weakness)

due to small cell lung carcinoma

Question 5

EPO

Answer 5

leads to polycythemia

due to renal cell carcinoma, hemangioblastoma, hepatocellular cacinoma, leiomyoma, pheochromocytoma

Question 6

PTHrP

Answer 6

leads to hypercalcemia

due to squamous cell lung carcinoma, renal cell carcinoma, breast cancer