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Oncogenes Flashcards

1
Q

BCR-ABL

A

t(9;22)
tyrosine kinase
CML, ALL

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2
Q

BCL-2

A

t(14;18)
antiapoptotic (inhibits apoptosis)
Follicular and undifferentiated lymphomas

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3
Q

BRAF

A

serine/threonine kinase
Melanoma**
non-hodgkin lymphoma

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4
Q

c-kit

A

Cytokine receptor

gastrointestinal stromal tumor (GIST)

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5
Q

c-myc

A

t(8;14)
transcription factor
Burkitt lymphoma

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6
Q

HER2/neu (c-erbB2)

A

tyrosine kinase

breast, ovarian, gastric carcinomas

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7
Q

L-myc

A

transcription factor

Lung cancer

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8
Q

N-myc

A

transcription factor

Neuroblastoma

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9
Q

RAS

A

GTPase

colon cancer, lung cancer, pancreatic cancer

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10
Q

RET

A

tyrosine kinase
MEN2A and MEN 2B
medullary thyroid cancer**

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