Tumor Markers And Oncogenes Flashcards
At which chromosome is BRCA1 Mutation located?
Ch. 17
Mechanism of action of Normal BRCA gene.
DNA repair (tumor suppressor gene)
What is the tumor marker used for follow up of breast cancer
CA15-3
What laboratory investigations would you recommend to
differentiate between liver and bone metastasis?
GGT
What is the mechanism underlying hypercalcemia in cancer? (enzyme)
due to 1 alpha hydroxylase
Sameh El Basty is 60-year-old man working as a lawyer in criminal
court coming to ED complaining of abdominal pain, back pain, loss of
appetite, fatigue, weight loss, yellowish discoloration of sclera and
dark urine.
His physical examination is remarkable for jaundice and large left
upper abdominal mass. CT scan of his abdomen revealed an irregular
infiltrating mass in the body of the pancreas. A group of tumor
markers were ordered along with other laboratory tests.
Whaf is the tumor marker recommended
CA 19. 9
It’s recommended for gastrointestinal malignancies such as cholangiocarcinoma, pancreatic cancer and colon cancer
Which tumor marker most likely used for hepatocellular carcinoma?
AFP
What are molecular investigations do you recommend in lung cancer
EGFR, ALK & ROS1 mutation molecular testing to to determine
suitability for EGFR- TKI therapy and other treatment option
Tumor marker for prostate cancer
PSA
A patient is presenting with symptoms suggesting prostate cancer, the dr performed a digital rectal examination and ordered a serum PSA level,
When should the patient do the labs?
. Immediately
. After 3 days
. After 1 week
Answer: after 3 days.
Explanation: consider delaying PSA sampling until 3 days after a digital rectal examination. Local guidelines may vary, but
many institutions either take PSA levels before DRE or introduce a delay post-DRE to PSA sampling to reduce the
likelihood of falsely elevated PSA results secondary to prostatic stimulation.
