Management Of Hepatocellular Carcinoma

Question 1

A patient is diagnosed with Hepatocellular carcinoma,
The tumor is <2 cms, with preserved liver function.

What is the stage and how to treat it?
What is the prognosis?

Answer 1

Very early stage
Tx: ablation or resection
Prognosis: >5 yrs

Question 2

A patient is diagnosed with Hepatocellular carcinoma,
The tumor is multinodular, unresectable with preserved liver function,

What stage is this and what is the treatment?
What is the prognosis?

Answer 2

Stage: intermediate
Tx: Chemoembolisation
Prognosis: >2.5 yrs

Question 3

A patient is diagnosed with Hepatocellular carcinoma with portal invasion and preserved liver function, PS 1-2
What is the stage and how to treat it
What is the prognosis?

Answer 3

Stage: advanced
Tx: systemic therapy (Sorafinib)
Prognosis: >10 months

Question 4

A patient is diagnosed with Hepatocellular carcinoma (terminal stage), His parents are concerned about how much he has left to live and what can we do to him at the moment.
What is the management of this case?
What is the prognosis of this stage of cancer?

Answer 4

Management :BSC
Prognosis: 3 months

Question 5

What is the first line systemic therapy (MAb) used for Hepatocellular carcinoma

Answer 5

Lenvatinib

Question 6

What is the first standard of care (systemic therapy) for advanced Hepatocellular carcinoma?

Answer 6

Sorafinib