Complications Of Hematological Malignancy

Question 1

Most important precautions that should be available in isolation rooms of transplantation.

Answer 1

• Central or point-of-use HEPA (99.97% efficiency) filters capable of
removing particles 0.3 μm in diameter for supply (incoming) air
• Well-sealed rooms
• Positive room air pressure in relation to the corridor
• Self-closing door on all room exits

Question 2

what is the absolute neutrophilic count (ANC) below which
prophylactic antibiotics are required in transplantation?

Answer 2

<0.5 x 109/L

Question 3

Why should prednisolone be used in patients undergoing bone marrow transplantation

Answer 3

To protect against graft vs host disease

Question 4

A patient undergoes bone marrow transplantation, he then developed Graft vs Host Disease,
What is the management?

Answer 4

. Corticosteroids
. Ruxolitinib if steroids resistant

Question 5

Management of hyperkalemia in tumor lysis syndrome

Answer 5

. Ca gluconate. If ECG changes.
. Insulin +glucose
. Nebulised B2 agonist
. K binders
. RRT.

Question 6

Prevention and management of tumor lysis syndrome

Answer 6

. Allopurinol and fluids
. Rasburicase

Question 7

How to confirm diagnosis of multiple myeloma

Answer 7

Immune fixation
Electrophoresis (M spike)