Molecular Basis Of Cancer

Question 1

Gastrointestinal stromal tumors receptors activated is….

Answer 1

c-Kit receptor TK domain

Question 2

Receptors activated in Lung cancer

Answer 2

EGFR 1 gene amplification

Question 3

What are the Receptors activated in breast cancer?

Answer 3

Her2/neu (EGFR-2)

Question 4

Genetic mutation in chronic myeloid leukemia

Answer 4

Chromosome 9: 22 translocation causes bcr-abl fusion protein withactivated Abl tyrosine kinas

Question 5

Raf mutations are involved in which type of cancers

Answer 5

Melanomas

Question 6

What is the drug used for ER +ve breast cancer?

Answer 6

Ribociclib

Question 7

Role of Ribociclib in ER+ve breast cancer

Answer 7

downregulating cyclin D–CDK4/6 activity

Question 8

What is the effect of matrix metalloproteinases (MMP) secreted by the tumor on host tissue?

Answer 8

Destroys it (degradation of ECM)

Question 9

In poorly differentiated tumors, there is a (high/low) quantity of E-Cadherin.

Answer 9

Low

Question 10

Mechanism of action of MARIMASTAT

Answer 10

Inhibitor of Matrix metalloproteinases (MMP)

Question 11

What is the effect of VEGF (vascular endothelial growth factor) on blood vessels?

Answer 11

Induces angiogenesis (abnormal in tumors)

Question 12

Mechanism of action of Bevacizumab

Answer 12

Anti VEGF

Question 13

Mechanism of action of Ramicirumab

Answer 13

Anti VEGF receptor

Question 14

Mechanism of action of Vioxx

Answer 14

Coxx 2 inhibitor

Question 15

What happens to the Telomere in cancer cells to be able to have a limitless replicative potential

Answer 15

Telomere Extension by Telomerase