Systemic Anticancer Treatment Flashcards
Antimetabolites inhibit which phase of cell cycle
S phase
Antibiotics inhibit which phase of cell cycle?
Part of G1,
S phase
Part of G2
Vinca alkaloids inhibit which phase of cell cycle
1st part of mitosis
Taxoids inhibits which phase of cell cycle?
Last part of M phase
1st part of G1
Alkylating agents inhibit which part of cell cycle
All of the cell cycle
What are the 3 subtypes of antimetabolites
Pyrimidine
Purines
Antifolates
Give examples of pyrimidine antimetabolites
5 FU
Capecitabine
Give 2 examples of antifolates
Methotrexate
Pemetrexed
Major antitumor mechanism of 5FU
Inhibition of thymidine synthethase
Mechanism of action of Methotrexate
DiHydroFolate Reductase inhibitor
Give examples of Purines antimetabolites
6 MP
Thioguanine
Fludarabine
Cladribine
6MP & Thioguanine are ised to treat which type of leukemia
ALL
Fludarabine is used to treat which type of leukemia
CLL
Cladribine is used for tx of which type of leukemia
Hairy cell leukemia
Mention types of Anticancer antibiotics
Anthracyclines
• Doxorubicin/adriamycin
• Daunorubicin
• Epirubicin
• Idarubicin
Bleomycin
Actinomycin D/dactinomycin
Main toxicities of anthracyclines
Alopecia
Cardiotoxicity
Cumulative dose of antibiotics in cancer
500 mg/m2
Mechanism of action of antibiotics in cancer
DNA binding
Topoisomerase 2 inhibitor
Free radical formation
Mechanism of action of alkylating agents
Transfer of alkyl group from one molecule to another
Mention typea of alkylating agents
Classic
Non classic
Mention examples of classic alkylating agents
Nitrogen mustards
Aziridines: Thiotepa
Mention examples of non classic alkylating agents
Platimums: cisplatin, carboplatin
Mention toxicity of alkylating agents
MAN:
Myelosuppression
Alopecia
N&V
Menttion examples of Topoisomerase 1 inhibitors
Topotecan
Irinotecan
Mention examples of Topoisomerase 2 inhibitors
Intercalating: Doxorubicin
Non intercalating: etoposide, tenoposide
Mention types of tubulin binding agents
Vinca alkaloids
Taxanes
Mention examples of vinca alkaloids
Vinblastine
Vincristine
Mention examples of tanxanes
Paclitaxel
Docetaxel
Which of the vinca alkaloids is used for testicular cancer
Vinblastine
Which of the vinca alkaloids is used for leukemia, lymphoma?
Vincristine
Which of the vinca alkaloids is used for breast and lung cancer
Vinorelbine
Which of the Taxanes is used for ovarian cancer
Epothilones
Which of the Taxanes is used to treat breast and lung cancer
Docetaxel
Paclitaxel (Taxanes) is used to treat which cancers
Breast and ovary
What is the tubulin binding agent used for treatment of prostate cancer
Estramustine
A patient has been diagnosed with cancer, the doctor prescribed Bevacizumab for her,
what is the mechanism of action of Bevacizumab?
And what are the side effects that can occur due to it?
MOA: anti-VEGF
SE: bleeding, VTE, HTN
A patient has been diagnosed with cancer,
The doctor prescribed Gefitinib because it acts on a mutation in receptors.
What is the receptor mutation for which Gefitinib is used?
What are the side effects of Gefitinib?
EGFR mutation
Side effects: skin toxicity, tx moisturizers
Mention one immunotherapy (anti PD1) receptor
Pembrolizumab
