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OPEC > Systemic Anticancer Treatment > Flashcards

Systemic Anticancer Treatment Flashcards

1
Q

Antimetabolites inhibit which phase of cell cycle

A

S phase

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2
Q

Antibiotics inhibit which phase of cell cycle?

A

Part of G1,
S phase
Part of G2

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3
Q

Vinca alkaloids inhibit which phase of cell cycle

A

1st part of mitosis

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4
Q

Taxoids inhibits which phase of cell cycle?

A

Last part of M phase
1st part of G1

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5
Q

Alkylating agents inhibit which part of cell cycle

A

All of the cell cycle

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6
Q

What are the 3 subtypes of antimetabolites

A

Pyrimidine
Purines
Antifolates

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7
Q

Give examples of pyrimidine antimetabolites

A

5 FU
Capecitabine

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8
Q

Give 2 examples of antifolates

A

Methotrexate
Pemetrexed

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9
Q

Major antitumor mechanism of 5FU

A

Inhibition of thymidine synthethase

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10
Q

Mechanism of action of Methotrexate

A

DiHydroFolate Reductase inhibitor

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11
Q

Give examples of Purines antimetabolites

A

6 MP
Thioguanine
Fludarabine
Cladribine

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12
Q

6MP & Thioguanine are ised to treat which type of leukemia

A

ALL

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13
Q

Fludarabine is used to treat which type of leukemia

A

CLL

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14
Q

Cladribine is used for tx of which type of leukemia

A

Hairy cell leukemia

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15
Q

Mention types of Anticancer antibiotics

A

Anthracyclines
• Doxorubicin/adriamycin
• Daunorubicin
• Epirubicin
• Idarubicin
Bleomycin
Actinomycin D/dactinomycin

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16
Q

Main toxicities of anthracyclines

A

Alopecia
Cardiotoxicity

17
Q

Cumulative dose of antibiotics in cancer

A

500 mg/m2

18
Q

Mechanism of action of antibiotics in cancer

A

DNA binding
Topoisomerase 2 inhibitor
Free radical formation

19
Q

Mechanism of action of alkylating agents

A

Transfer of alkyl group from one molecule to another

20
Q

Mention typea of alkylating agents

A

Classic
Non classic

21
Q

Mention examples of classic alkylating agents

A

Nitrogen mustards
Aziridines: Thiotepa

22
Q

Mention examples of non classic alkylating agents

A

Platimums: cisplatin, carboplatin

23
Q

Mention toxicity of alkylating agents

A

MAN:
Myelosuppression
Alopecia
N&V

24
Q

Menttion examples of Topoisomerase 1 inhibitors

A

Topotecan
Irinotecan

25
Q

Mention examples of Topoisomerase 2 inhibitors

A

Intercalating: Doxorubicin
Non intercalating: etoposide, tenoposide

26
Q

Mention types of tubulin binding agents

A

Vinca alkaloids
Taxanes

27
Q

Mention examples of vinca alkaloids

A

Vinblastine
Vincristine

28
Q

Mention examples of tanxanes

A

Paclitaxel
Docetaxel

29
Q

Which of the vinca alkaloids is used for testicular cancer

A

Vinblastine

30
Q

Which of the vinca alkaloids is used for leukemia, lymphoma?

A

Vincristine

31
Q

Which of the vinca alkaloids is used for breast and lung cancer

A

Vinorelbine

32
Q

Which of the Taxanes is used for ovarian cancer

A

Epothilones

33
Q

Which of the Taxanes is used to treat breast and lung cancer

A

Docetaxel

34
Q

Paclitaxel (Taxanes) is used to treat which cancers

A

Breast and ovary

35
Q

What is the tubulin binding agent used for treatment of prostate cancer

A

Estramustine

36
Q

A patient has been diagnosed with cancer, the doctor prescribed Bevacizumab for her,
what is the mechanism of action of Bevacizumab?
And what are the side effects that can occur due to it?

A

MOA: anti-VEGF
SE: bleeding, VTE, HTN

37
Q

A patient has been diagnosed with cancer,
The doctor prescribed Gefitinib because it acts on a mutation in receptors.
What is the receptor mutation for which Gefitinib is used?
What are the side effects of Gefitinib?

A

EGFR mutation
Side effects: skin toxicity, tx moisturizers

38
Q

Mention one immunotherapy (anti PD1) receptor

A

Pembrolizumab

OPEC (23 decks)

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