Tumor markers

Question 1

AFP aka?

Answer 1

Alpha-fetoprotein

Question 2

AFP cancer types?

Answer 2

Liver cncer

germ cell tumors

Question 3

AFP tissue analyzed?

Answer 3

blood

Question 4

AFT how used?

Answer 4

dx liver CA and follow response to tx, assess stage, prognosis and respond to treatment for germ cell tumor

Question 5

BRAF mutation V600E cancer types?

Answer 5

cutaneous melanoma and colorectal CA

Question 6

BRAF tissue analyzed?

Answer 6

tumor

Question 7

BRAF how used?

Answer 7

predict response to therapies

Question 8

CA19-9 cancer types?

Answer 8

pancreatic CA, GB CA, bile duct CA, gastric CA

Question 9

CA19-9 tissue analyzed?

Answer 9

blood

Question 10

CA19-9 how used?

Answer 10

assess whether tx is working

Question 11

CA125 cancer type?

Answer 11

Ovarian CA

Question 12

CA125 tissue analyzed?

Answer 12

blood

Question 13

CA125 how used?

Answer 13

dx, assessment of response to tx and evaluation of recurrance

Question 14

CEA aka?

Answer 14

Carcinoembryonic antigen

Question 15

CEA cancer types?

Answer 15

colorectal CA and breast CA

Question 16

CEA tissue analyzed?

Answer 16

blood

Question 17

CEA how used?

Answer 17

check whether colorectal CA has spread, look for breat CA recurrence and response to tx

Question 18

CD20 cancer type?

Answer 18

non-hodgkin lymphoma

Question 19

CD20 tissue analyzed?

Answer 19

blood

Question 20

CD20 how used?

Answer 20

determine if tx therapy is appropriate

Question 21

KIT cancer types?

Answer 21

GI stromal tumor and mucosal melanoma

Question 22

KIT tissue analyzed?

Answer 22

tumor

Question 23

KIT how used?

Answer 23

dx and determine tx

Question 24

function of schilling test?

Answer 24

Function: Absorption of B12 is dependent on 2 factors

1. IF to absorb B12
2. have to have normal illial absorption

Question 25

Schilling test stage 1?

Answer 25

Stage I: Radiolabeled B12 is given PO and then 24 hour urine completed

Question 26

Schilling test stage 2?

Answer 26

Stage II: 5 days later, test repeated with intrinsic factor

Question 27

Schilling test: Abnl stage I and NL stage II?

Answer 27

pernicious anemia ( they only lack IF)

Question 28

Schilling test: Abnl stage I and stage II?

Answer 28

ileal malabsorption ( something wrong with ileum)

Question 29

Antiparietal cell Ab function?

Answer 29

Parietal cells produce intrinsic factor

Looking for ab against parietal cells then they are destroying their parietal cells and this no IF

Question 30

Antiparietal cell Ab is found in about __% of patients with p. anemia and about __-__% in the normal pop.

Answer 30

90%

10-15%

Question 31

Antiparietal cell Ab is a good _________ test and schilling is a ________________.

Answer 31

good screening test and schilling in a conformation test