Tuberculosis and Leprosy Flashcards
1
Q
Mycobacteria (4)
A
M.tuberculosis
M.leprae
M.bovis
M.avium
2
Q
Tuberculosis
- contagious?
A
- latent or active
- YES, through air
3
Q
Extrapulmonary TB
- infects?
A
- miliary tuberculosis
- infects multiple organ systems
4
Q
M.tuberculosis
- intra/extracellular?
- lives?
- generation time?
A
- intracellular
- in macrophages
- slow
5
Q
M.tuberculosis = Cell Envelope
- high concentration ___
- ____ to stains
- gram __ acid fast stain (test for ___)
A
- mycolic acid
- impermeability
- gram POSITIVE
- test for mycolic acid
6
Q
Tuberculosis - Progression (4)
A
1) Transmission
2) Phagocytosis
3) Granulomas form. T-cell Activated Macrophage
4) Tubercle grows
7
Q
Transmission
A
- inhalation from infect host
8
Q
Phagocytosis
- TB cells blocks ___
- TB inhibits _____
- TB multiplies in ____
A
- blocks acidification of phagosome
- inhibits fusion of lysosome
- macrophages
9
Q
______ Form
- ___ destroy pathogens
- balance between pathogen + host = ___
A
- Granulomas
- tubercles
- latent TB
10
Q
____ Activated Macrophage
- secrete ___, activate ___
- chronic ___ –> ____
A
- T-Cell
- cytokines, macrophages
- inflammation –> necrosis
11
Q
___ Grows
- why?
- ____ erosion = route of transmission
- no host immunity?
- cavitation?
A
- Tubercle
- some macrophages inactivated or infected
- granuloma erosion
- ACTIVE TB
- center liquefy
12
Q
ESX Secretion Systems
- how many exist in Mtb?
- transport ___ across Mtb _____
- damage ____
- inhibit ___
A
- 5 ESX Systems
- bacterial molecules, cell envelope
- phagosome
- immune responses
13
Q
Multi-drug resistant TB
- resistant to?
A
1st line drugs
14
Q
Extensively-drug resistant TB
- resistant to?
A
2nd line drugs
15
Q
What test for TB?
- inject with?
- look for?
- infected goes from
A
Tuberculin Test
- purified protein M.tuberculosis
- T cell-mediated response
- goes from negative to positive if infected
