Lyme Disease

Question 1

____ of polyarthritis in children

Answer 1

epidemic

Question 2

what is the bacteria responsible for Lyme Disease?

Answer 2

Borrelia burgdorferi

Question 3

Borrelia burgdorferi

• gram?
• shape?
• __ borne disease

Answer 3

• gram NEGATIVE
• spirochete
• vector-borne

Question 4

Life Cycle of Tick

- requires __ between stages

Answer 4

• larva -> nymph -> adult
• requires blood
• must acquire B.burgdorferi

Question 5

Transmission of Tick

• secretes ___
• transmission time
• which stage of life cycle?

Answer 5

• local anesthetic
• more than 24 hours
• nymph

Question 6

B.burgdorferi - Reservoir

• transmitted to host through ___
• which animal?

Answer 6

• TICKS

- white footed mice

Question 7

hematogenous dissemenination

Answer 7

spread in blood

Question 8

B.burgdorferi - Transmission

• __ saliva inhibits __ function
• decreases (4)

Answer 8

• tick, DC
• phagocytosis
• maturation
• inflammatory mediators
• antigen presentation

Question 9

B.burgdorferi - Characteristics

• periplasmic ___ called ___ filaments
• Unusual ___ and ___

Answer 9

• flagella, axial

- membrane and genetic structure

Question 10

B.burgdorferi - flagella

• __ around cells
• move in ___ fashion

Answer 10

• wrap

- cork-screw

Question 11

B.burgdorferi - Unusual Membrane

• NO ___
• many surface expressed lipoproteins called ___
• ___ to slow down escape

Answer 11

• LPS
• adhesions
• adhesions

Question 12

B.burgdorferi - Unusual Genetic Structure

• ___ chromosome
• ___ plasmids
• ___ metabolic capacity

Answer 12

• linear
• multiple
• limited

Question 13

Infection 3 Stages

Answer 13

• Early (localized) stage
• Early (disseminated) stage
• Late (disseminated) stage

Question 14

Early Localized Stage

• erythema migrans?
• affects?

Answer 14

• painless Bulls eye rash

- groin, axilla, waist, back

Question 15

Early Disseminated Stage

• type of patients?
• multiple __
• symptoms?

Answer 15

• untreated
• rashes
• pain + swelling of joints, heart palpitations, meningitis

Question 16

Late Disseminated Stage

• can cause?
• symptoms?

Answer 16

• Long Term disability

- muscle pain, arthritis

Question 17

Blood Brain Barrier

• type?
• using what mechanism?

Answer 17

• Paracellular

- flagella

Question 18

10-20% experience symptoms AFTER treatment

Answer 18

Post-Treatment Lyme Disease

Question 19

Diagnosis

Answer 19

• erythema migrans
• tick bite
• anti-B.burgdorferi antibody test (false -)

Question 20

Treatment

- antibiotics how long

Answer 20

2-4 weeks

Question 21

Chronic Lyme Disease

• diagnosed __ evidence of prior Lyme Disease
• __ symptoms

Answer 21

CONTROVERSIAL

• without
• persistant

Question 22

Lyme Disease Vaccine

• name?
• how effective?
• ___ high risk areas
• claims of?
• pulled due to?

Answer 22

• LYMErix
• 75%
• considered
• cause arthritis
• lack of demand