Lyme Disease Flashcards
1
Q
____ of polyarthritis in children
A
epidemic
2
Q
what is the bacteria responsible for Lyme Disease?
A
Borrelia burgdorferi
3
Q
Borrelia burgdorferi
- gram?
- shape?
- __ borne disease
A
- gram NEGATIVE
- spirochete
- vector-borne
4
Q
Life Cycle of Tick
- requires __ between stages
A
- larva -> nymph -> adult
- requires blood
- must acquire B.burgdorferi
5
Q
Transmission of Tick
- secretes ___
- transmission time
- which stage of life cycle?
A
- local anesthetic
- more than 24 hours
- nymph
6
Q
B.burgdorferi - Reservoir
- transmitted to host through ___
- which animal?
A
- TICKS
- white footed mice
7
Q
hematogenous dissemenination
A
spread in blood
8
Q
B.burgdorferi - Transmission
- __ saliva inhibits __ function
- decreases (4)
A
- tick, DC
- phagocytosis
- maturation
- inflammatory mediators
- antigen presentation
9
Q
B.burgdorferi - Characteristics
- periplasmic ___ called ___ filaments
- Unusual ___ and ___
A
- flagella, axial
- membrane and genetic structure
10
Q
B.burgdorferi - flagella
- __ around cells
- move in ___ fashion
A
- wrap
- cork-screw
11
Q
B.burgdorferi - Unusual Membrane
- NO ___
- many surface expressed lipoproteins called ___
- ___ to slow down escape
A
- LPS
- adhesions
- adhesions
12
Q
B.burgdorferi - Unusual Genetic Structure
- ___ chromosome
- ___ plasmids
- ___ metabolic capacity
A
- linear
- multiple
- limited
13
Q
Infection 3 Stages
A
- Early (localized) stage
- Early (disseminated) stage
- Late (disseminated) stage
14
Q
Early Localized Stage
- erythema migrans?
- affects?
A
- painless Bulls eye rash
- groin, axilla, waist, back
15
Q
Early Disseminated Stage
- type of patients?
- multiple __
- symptoms?
A
- untreated
- rashes
- pain + swelling of joints, heart palpitations, meningitis
