Trimethoprim Flashcards
What does trimethoprim do to bacteria?
It inhibits the enzyme dihydrofolic reductase so no THF is formed
Trimethoprim is 20-50 times _____ (more/less) potent than sulfamethoxazole
more potent
What is trimethoprim used for?
UTI
Bacterial prostatitis
Trimethoprim undergoes ___________ (acetylation/O-demethylation) and mainly excreted in urine
O-demethylation
What are the side effects of trimethoprim
Folic acid deficiency (megaloblastic anemia, granulocytopenia, leukopenia)
Hyperkalemia
Who are at more risk of developing folic acid deficiency?
Pregnant patients
People taking nutrient poor diet
Who are at risk for developing hyperkalemia if taking trimethoprim?
Patients who are already taking ACE inhibitors or potassium sparing drugs (diuretics)
Why is trimethoprim used for prostatic and vaginal infections
Trimethoprim is a weak base so it concentrates more easily in the acidic prostatic and vaginal fluids
Does trimethoprim enters CSF?
Yes
How to prevent folic acid deficiency if taking trimethoprim?
Leucovorin (folinic acid) enters the human cells not bacteria
Trimethoprim use can lead to __________ (megaloblastic/microcytic) anemia
megaloblastic anemia
