Other Cell Wall Inhibitors Flashcards
Vancomycin Lipoglycopeptides Daptomycin Fosfomycin Polymyxin
Vancomycin is used for the treatment of what?
Skin and soft tissue infxns
Inf. endocarditis
Nosocomial pneumonia
Lipoglycopeptides are used for tx of what?
Acute bacterial skin and skin structure infections *(ABSSSI)
Nosocomial pneumonia
Daptomycin is used for tx of what?
Complicated skin/skin structure infxns
Bacteremia
Right sided Infective endocarditis
What is fosfomycin used for?
UTI
Acute cystitis
What is the MOA of fosfomycin
Inhibits the enzyme (enolpyruvyl transferase) that inhibit peptidoglycan synthesis
__________ shouldn’t be used for tx of pneumonia bcz surfactant inactivates this drug
Daptomycin
Lipoglycopeptides shouldn’t be used if…
Pregnant
Renal disease
Taking other drugs that prolong QTc intervals(fluoro/macrolides)
AMS of daptomycin
MRSA
Vancomycin resistant enterococci(VRE)
Name the lipoglycopeptides
Telavancin
Oritavancin
Dalbavancin
AMS of lipoglycopeptides (LPGP)
Gram +ve (staph, strept, enterococci)
LPGP is _____ (more/less) potent than vancomycin
more
What is the AMS of vancomycin
G +ve (Aerobic, anaerobic, MRSA, MRSE, C difficile, enterococci)
Vancomycin dose depends on _______ (hepatic/renal) functions
renal
We have to monitor __________ when giving vancomycin
creatinine clearance
Oral vancomycin is used for __________ infxn
C difficile
