Protein Synthesis Inhibitors

Question 1

___________ (Tetracyclines/Amphenicols) are derivatives of naphthacene carboxamide

Answer 1

Tetracyclines

Question 2

Tetracyclines bind reversibly to the ____ (50S/30S) subunit of bacterial ribosomes

Answer 2

30S

Question 3

Tetracyclines are _________ (bactericial/bacteriostatic) agents.

Answer 3

bacteriostatic

Question 4

Tetracylines block the attachment of _____ (mRNA/tRNA) on the ribosomes.

Answer 4

tRNA (prevents the binding of aminoacyl tRNA to the acceptor site on the mRNA–ribosome
complex)

Question 5

Resistance to tetracylines is _________-mediated

Answer 5

plasmid

Question 6

Absorption of tetracyclines is impaired by ________

(stomach/intestinal) contents, especially milk and antacids.

Answer 6

stomach

Question 7

___________, (minocycline/tigecycline) an exception, is only administered
IV.

Answer 7

Tigecycline

Question 8

Therapeutic concentrations in the brain and CSF can be achieved with ______ (demeclocycline/minocycline)

Answer 8

minocycline

Question 9

The primary route of elimination for most tetracyclines is the __________ (kidney/liver)

Answer 9

kidney

Question 10

___________ and ___________ do not accumulate and hence are the safest tetracycline to administer to individuals with impaired renal function. (doxycycline/oxytetracycline/tigecycline/demeclocycline)

Answer 10

Doxycycline and tigecycline

Question 11

Many tetracyclines undergo ___________ recirculation

Answer 11

enterohepatic

Question 12

Tetracyclines are active against what kind of bacteria?

Answer 12

Both gram-negative and gram-positive organisms

Question 13

Tetracyclines are used predominantly for the treatment of ___________ infections

Answer 13

Rickettsial

Question 14

Tetracyclines are used to treat _______ and chlamydia infxns

Answer 14

acne

Question 15

Minocycline also achieves high concentrations in three places.

Answer 15

Endolymph
Saliva
Tears

Question 16

________ is preferred in patients with renal dysfunction as it is excreted in feces

Answer 16

Doxycycline

Question 17

Vertigo and tinitus are more pronounced with the use of ___________

Answer 17

Minocycline

Question 18

Esophagitis may be minimized by _____________ and with the use of capsules

Answer 18

administration of food

Question 19

What is pseudotumor cerebri?

Answer 19

Benign intracranial HTN characterized by headache and dizziness.

Question 20

What are effects of tetracycline depositing in calcified tissues?

Answer 20

Discoloration and hypoplasia of teeth

Temporary stunting of growth

Question 20

What are effects of tetracycline depositing in calcified tissues?

Answer 20

Discoloration and hypoplasia of teeth

Temporary stunting of growth

Question 21

What things decrease the absorption of tetracycline?

Answer 21

Dairy products
Iron supplements
Ca, Mg and Al Antaacids

Question 22

Sunburn is more frequently with the use of ___________ and _____________

Answer 22

Tetracycline

Demeclocycline

Question 23

Tetracyclines should be taken __________

a. on an empty stomach
b. with food

Answer 23

on an empty stomach

Question 24

Cations form nonabsorbable _________ with tetracyclines

Answer 24

chelates

Question 25

Is pseudotumor cerebri due to tetracycline reversible or irreversible?

Answer 25

reversible

Question 26

____________ and minocycline are available as IV and oral preparations

Answer 26

Doxycycline

Question 27

Tetracyclines _______ (cross/do not cross) the placental barrier

Answer 27

cross

Question 27

Tetracyclines _______ (cross/do not cross) the placental barrier

Answer 27

cross

Question 28

Can pregnant and lactating women take tetracycline?

Answer 28

nO

Question 29

What is the minimum age in which children can take tetracycline?

Answer 29

8 and above