B Lactamase Inhibitors Flashcards
Beta lactamase inhibitors have two types.
What are they?
One that has Blactam ring. One that doesnt
Name the ones that have the ring.
Clavulanic acid
Sulbactam
Tazobactam
Name the ones that don’t have the ring.
Avibactam
Vabrobactam
Ceftolozane-__________ is given IV
Tazobactam
Ceftolozane-tazobactam is used for tx of gram _________ (positive/negative) infection
negative
WHat is the antimicrobial spectrum of ceftolozane-tazobactam
Resistant enterobacteriaceae
Resistant P aeruginosa
Some activity against ESBLs, gram +ve, and anaerobic bacteria
Ceftazidime-__________ is also given IV
avibactam
What is the antimicrobial spectrum of ceftazidime-avibactam
Broad gram -ve (enterobac., p aeruginosa)
Low activity against g +ve and anaerobes
What is the exception of gram -ve bacteria that can’t be treated by ceftazidime-avibactam?
Acinetobacter
Name some types of B-LACTAMASES.
AmpC
ESBL
Carbapenemase
Metallo B Lactamase
Ceftizidime-avibactam cannot resist hydrolysis if _________ (b-lactamase) is in the game.
Metallo B lactamase
What is ceftazidime-avibactam used for? (2)
intraabdominal infxn
Complicated UTIs
(reserved for multidrug resistance)
This carbapenem-B lactamase Inhibitor is used for the tx of complicated UTI
Meropenem-vaborbactam
AMS of meropenem-vaborbactam
Enterobacteriaceae
