Other Beta Lactam Antibiotics Flashcards
What is the difference between carbapenems and monobactams
monobactam doesnot have a thiazolidine ring instead it only has a beta lactam ring
What is the difference between carbapenem and penicillin?
The sulfur atom of thiazolidine ring of penicillin is externalized and replaced by a carbon atom in carbapenems
Name the carbapenems (not worth a DIME)
Doripenem
Imipenem
Meropenem
Ertapenem
Carbapenems undergo hydrolysis by ___________ (b lactamase/metallo B lactamase)
metallo b lactamase
carbapenems are not affected by ___________ (b lactamase/metallo B lactamase)
b lactamase
Carbapenems are used as ________ therapy for Blactam g +ve, g -ve, anaerobes and p. aeruginosa
empiric
____________ (carbapenem) has no activity against P. aeruginosa, enterobacteraccea and acinetobacter species
Ertapenem
Carbapenem are given ________
IV
Does carbapenem penetrate CSF?
When meninges are inflamed, they do penetrate.
Meropenem penetrate w/o inflammation
Carbapenems are excreted in _________
urine
Imipenem is cleaved by ____________ in the brush border of PCT
dehydropeptidase
Imipenem is combined w/ ________ which protects the parent drug from cleavage and prolongs half life
cilastatin
Is dose adjustment required for renal insufficiency if we give carbapenems and monobactams
Yes
What are the side effects of imipenem+cilastatin?
N/V/D
Eosinophilia and neutropenia less common
cross reactivity in some
__________ (carbapenem) can also provoke seizures
imipenem
What are the adverse effects of monobactams?
Phelbitis
Skin rash
Abnormal LFTs
Little cross reactivity
Monobactam is given ________
IV or IM
Aztreonam has no activity against __________ and __________
gram + organisms
anaerobes
Monobactam (Aztreonam) works only against ___________ and ____________
P. aeruginosa
Enterobacteriaceae
