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Clin Med B 2 > Trigger - Misc > Flashcards

Trigger - Misc Flashcards

1
Q

unsuccessful attempts at remyelination results in plaques and scaring

A

MS

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2
Q

Hypovitaminosis D predisposes you to what diagnosis

A

MS

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3
Q

symptoms worsen with increasing body temp

A

uthoff phenomenon in MS

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4
Q

Shock like sensation down legs

A

Lhermittes symptoms in MS

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5
Q

increased risk of optic neuritis and relative afferent pupil defect

A

eye problems in MS, theres alot more, i just put theswez

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6
Q

what cranial nerves are effected in MS

A

5,7,9

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7
Q

detrusor muscle hyperreflexia

A

MS

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8
Q

what is clinically isolated MS syndrome

A

first MS attack, must last 24 hrs. doesnt have to meet all criteria

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9
Q

what kind of tremor can present in MS

A

intention tremor

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10
Q

deterioration in function separate from attacks

A

secondary MS

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11
Q

steady decline in function from onset of disease. no remission or relapse

A

primary MS

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12
Q

waves of remission and relapse in functional status.

A

RRMS

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13
Q

marked delay in latency during evoked potential testing

A

diagnostic of MS even in asymptomatic patients

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14
Q

oligoclonal bands and intrathecal IgG on CSF analysis

A

diagnostic study for MS patients with Isolated syndrome or atypical presentation.

also may see mild WBC elevation

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15
Q

acute tx of MS meds

A

methylprednisolone

Plasma exchange if needed

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16
Q

what must ptts be tested for prior to being given disease modifying agents

A

hep A
hep B
hep C
VZV

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17
Q

what are indications for disease modifying drugs in MS? what are the modifying drugs

A

CIS w rilsent lesions or relapsing RRMS or SPMS

  • monoclonal abx (ocrevus)
  • oral therapies
  • platform injection therapies
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18
Q

BBW for irsk of progressive multifocal leukoencephalopathy. all pts MUST be tested for JC abx prior to therapy

A

Ocrevus (MAB) for MS

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19
Q

ampyra is used when

A

K+ channel blocker that is used in MS when LE weakness interferes with ambulation

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20
Q

magnesium, abx, corticosteroids are used as protective factors for what

A

cerebral palsy

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21
Q

leading cause of childhood disabiltiy

A

CP

22
Q

hand preference before 12 months, gross motor delay in year 1.

A

Cerebral palsy

23
Q

imaging can be cranial US, MRI of brain, or CT

A

Cerebral palsy

only do MRI if baby is >3 weeks

24
Q

usually follows trauma and presents with patchy bone demineralization, skin changes.

A

complex regional pain syndrome

25
Q

single limb prevented use via pain

A

Complex regional pain syndrome

26
Q

pain made worse by loud noises, light touch, motion and stress

A

Chronic regional pain syndrome

acute phase
3 months

27
Q

when does cyanosis/pallor and atrophy of subcutaneous tissue present. Joint fibrosis also present here

A

subacute stage of chronic regional pain syndrome

9 months

28
Q

edema resolves, skin is dry/pale/cool/shiny. joint stiffness progresses and osteoporosis can happen

A

chornic stage of chronic regional pain syndrome

29
Q

budapest criteria

A

chronic regional pain syndrome

30
Q

first line treatment is OT and PT

A

Chronic regional pain syndrome

31
Q

Fatal neurodegenetaive disease of both upper and lower motor neurons characterized by progressive loss of motor function

A

amyotrophic lateral sclerosisis

32
Q

what is the MC type of ALS

A

sporadic

33
Q

what is hte MCC of death in ALS

A

pneumonia

34
Q

Impaired astrocytes increase glutamate => increased Ca2+ uptake

too much ca = mitochonrial oxidative stress

A

pathophys of ALS

35
Q

drooling, amotional lability, involuntary laughing crying

A

bulbar dysfunction in ALS

involuntary laughing/crying = psuedobulbar affect syndrome

36
Q

EMG will show both acute and chronic denervation and reinnervation.

Both upper and lower motor neuron lesion dysfunction

A

ALS

37
Q

Only proven med that extends life in ALS patients

A

riluzole

inhibits release of glutamate (ALS = excess glutamate)

38
Q

Only used for pts with a SOD1 gene mutation

A

tofersen

39
Q

MC caused by sepsis

A

toxic metabolic encephalopathy

40
Q

diagnosis of exclusion

A

toxic metabolic encephalopathy

41
Q

asterixias, brisk DTRs , exagerated physiologic tremors

A

toxic-metabolic encephalopathy

42
Q

Cafe au lait spots

A

Neurofibromatosis

43
Q

soft, pea sized lesions that are nonpainful or tender

A

neurofibromas found in neurofibromatosis

44
Q

bowing of the lower legs

scoliosis

A

NF type 1

45
Q

compression of the pituitary, optic gliomas

A

NF type 1

46
Q

ADHD common in this disorer

A

NF type 1

47
Q

MCC of death in NF type 1

A

malignant tumor

48
Q

MC lesion in NF type 2

A

Benign, slow-growing tumor of the vestibulocochlear nerve

CN 8

49
Q

gradual hearing loss, tinnitus, ataxia, HA

A

NF type 2

50
Q

Multiple, non-cutaneous schwannomas without vestibular involvement

A

schwannomatosis

51
Q

Focal pain of neuropathic and nocipceptive nature
Focal numberness and weakness
Muscle atrophy

A

schwannomatosis

SOOOO PAINFULLLLLL

Clin Med B 2 (44 decks)

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