Trigger - Misc

Question 1

unsuccessful attempts at remyelination results in plaques and scaring

Answer 1

MS

Question 2

Hypovitaminosis D predisposes you to what diagnosis

Answer 2

MS

Question 3

symptoms worsen with increasing body temp

Answer 3

uthoff phenomenon in MS

Question 4

Shock like sensation down legs

Answer 4

Lhermittes symptoms in MS

Question 5

increased risk of optic neuritis and relative afferent pupil defect

Answer 5

eye problems in MS, theres alot more, i just put theswez

Question 6

what cranial nerves are effected in MS

Answer 6

5,7,9

Question 7

detrusor muscle hyperreflexia

Answer 7

MS

Question 8

what is clinically isolated MS syndrome

Answer 8

first MS attack, must last 24 hrs. doesnt have to meet all criteria

Question 9

what kind of tremor can present in MS

Answer 9

intention tremor

Question 10

deterioration in function separate from attacks

Answer 10

secondary MS

Question 11

steady decline in function from onset of disease. no remission or relapse

Answer 11

primary MS

Question 12

waves of remission and relapse in functional status.

Answer 12

RRMS

Question 13

marked delay in latency during evoked potential testing

Answer 13

diagnostic of MS even in asymptomatic patients

Question 14

oligoclonal bands and intrathecal IgG on CSF analysis

Answer 14

diagnostic study for MS patients with Isolated syndrome or atypical presentation.

also may see mild WBC elevation

Question 15

acute tx of MS meds

Answer 15

methylprednisolone

Plasma exchange if needed

Question 16

what must ptts be tested for prior to being given disease modifying agents

Answer 16

hep A
hep B
hep C
VZV

Question 17

what are indications for disease modifying drugs in MS? what are the modifying drugs

Answer 17

CIS w rilsent lesions or relapsing RRMS or SPMS

• monoclonal abx (ocrevus)
• oral therapies
• platform injection therapies

Question 18

BBW for irsk of progressive multifocal leukoencephalopathy. all pts MUST be tested for JC abx prior to therapy

Answer 18

Ocrevus (MAB) for MS

Question 19

ampyra is used when

Answer 19

K+ channel blocker that is used in MS when LE weakness interferes with ambulation

Question 20

magnesium, abx, corticosteroids are used as protective factors for what

Answer 20

cerebral palsy

Question 21

leading cause of childhood disabiltiy

Answer 21

CP

Question 22

hand preference before 12 months, gross motor delay in year 1.

Answer 22

Cerebral palsy

Question 23

imaging can be cranial US, MRI of brain, or CT

Answer 23

Cerebral palsy

only do MRI if baby is >3 weeks

Question 24

usually follows trauma and presents with patchy bone demineralization, skin changes.

Answer 24

complex regional pain syndrome

Question 25

single limb prevented use via pain

Answer 25

Complex regional pain syndrome

Question 26

pain made worse by loud noises, light touch, motion and stress

Answer 26

Chronic regional pain syndrome acute phase 3 months

Question 27

when does cyanosis/pallor and atrophy of subcutaneous tissue present. Joint fibrosis also present here

Answer 27

subacute stage of chronic regional pain syndrome 9 months

Question 28

edema resolves, skin is dry/pale/cool/shiny. joint stiffness progresses and osteoporosis can happen

Answer 28

chornic stage of chronic regional pain syndrome

Question 29

budapest criteria

Answer 29

chronic regional pain syndrome

Question 30

first line treatment is OT and PT

Answer 30

Chronic regional pain syndrome

Question 31

Fatal neurodegenetaive disease of both upper and lower motor neurons characterized by progressive loss of motor function

Answer 31

amyotrophic lateral sclerosisis

Question 32

what is the MC type of ALS

Answer 32

sporadic

Question 33

what is hte MCC of death in ALS

Answer 33

pneumonia

Question 34

Impaired astrocytes increase glutamate => increased Ca2+ uptake too much ca = mitochonrial oxidative stress

Answer 34

pathophys of ALS

Question 35

drooling, amotional lability, involuntary laughing crying

Answer 35

bulbar dysfunction in ALS involuntary laughing/crying = psuedobulbar affect syndrome

Question 36

EMG will show both acute and chronic denervation and reinnervation. Both upper and lower motor neuron lesion dysfunction

Answer 36

ALS

Question 37

Only proven med that extends life in ALS patients

Answer 37

riluzole inhibits release of glutamate (ALS = excess glutamate)

Question 38

Only used for pts with a SOD1 gene mutation

Answer 38

tofersen

Question 39

MC caused by sepsis

Answer 39

toxic metabolic encephalopathy

Question 40

diagnosis of exclusion

Answer 40

toxic metabolic encephalopathy

Question 41

asterixias, brisk DTRs , exagerated physiologic tremors

Answer 41

toxic-metabolic encephalopathy

Question 42

Cafe au lait spots

Answer 42

Neurofibromatosis

Question 43

soft, pea sized lesions that are nonpainful or tender

Answer 43

neurofibromas found in neurofibromatosis

Question 44

bowing of the lower legs scoliosis

Answer 44

NF type 1

Question 45

compression of the pituitary, optic gliomas

Answer 45

NF type 1

Question 46

ADHD common in this disorer

Answer 46

NF type 1

Question 47

MCC of death in NF type 1

Answer 47

malignant tumor

Question 48

MC lesion in NF type 2

Answer 48

Benign, slow-growing tumor of the vestibulocochlear nerve CN 8

Question 49

gradual hearing loss, tinnitus, ataxia, HA

Answer 49

NF type 2

Question 50

Multiple, non-cutaneous schwannomas without vestibular involvement

Answer 50

schwannomatosis

Question 51

Focal pain of neuropathic and nocipceptive nature Focal numberness and weakness Muscle atrophy

Answer 51

schwannomatosis SOOOO PAINFULLLLLL